99mTc-HMPAO单光子发射计算机断层扫描在双相I型障碍抑郁发作患者中的临床价值

Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients.

作者信息

Benabarre Antoni, Vieta Eduard, Martín Francisco, Lomeña Francisco, Martínez-Aràn Anabel, Colom Francesc, Corbella Barbara, Gastó Cristóbal, Valdés Manuel

机构信息

Institut Clínic de Psiquiatria i Psicologia, Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036 Barcelona, Spain.

出版信息

Psychiatry Res. 2004 Dec 30;132(3):285-9. doi: 10.1016/j.pscychresns.2003.11.003.

DOI:10.1016/j.pscychresns.2003.11.003

PMID:15664800

Abstract

Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS).

摘要

采用单光子发射计算机断层扫描（SPECT）对17例符合双相I型抑郁症（DSM-IV标准）的患者进行了局部脑血流研究。图像的视觉分析显示，8例患者无异常，9例患者有异常发现。在这9例有异常发现的患者中，均显示（99m）锝-D，L-六甲基丙烯胺肟（HMPAO）摄取的局部降低（4例在额叶区域，2例在基底神经节，3例在额叶区域和基底神经节均有降低）。SPECT可见异常的患者在汉密尔顿抑郁评定量表（HDRS）上的得分显著更高。