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Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.

作者信息

Agarwal Anu, Srivastava Kumkum, Puri S K, Chauhan Prem M S

机构信息

Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.

出版信息

Bioorg Med Chem Lett. 2005 Feb 1;15(3):531-3. doi: 10.1016/j.bmcl.2004.11.052.

DOI:10.1016/j.bmcl.2004.11.052
PMID:15664807
Abstract

A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 microg/mL. These compounds are in vitro several times more active than cycloguanil.

摘要

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