来自狭叶风车子的DNA拓扑异构酶I抑制剂。

DNA topoisomerase I inhibitors from Rinorea anguifera.

作者信息

Ma Ji, Jones Shannon H, Marshall Rebekah, Wu Xihan, Hecht Sidney M

机构信息

Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, VA 22901, USA.

出版信息

Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6. doi: 10.1016/j.bmcl.2004.10.095.

DOI:10.1016/j.bmcl.2004.10.095

PMID:15664863

Abstract

An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.

摘要

为了鉴定负责稳定拓扑异构酶I-DNA共价二元复合物的天然成分，对从安圭拉风车子（Rinorea anguifera）中制备的有机提取物进行了研究。生物测定引导的分级分离导致分离出毛里求斯苷和（+）-丁香树脂醇作为新的拓扑异构酶I抑制剂，以及已知的抑制剂喜树碱。