嗜吞噬细胞无形体感染的中性粒细胞中吞噬作用存在缺陷。
Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils.
作者信息
Garyu Justin W A, Choi Kyoung-seong, Grab Dennis J, Dumler J Stephen
机构信息
Department of Pathology, Division of Medical Microbiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA.
出版信息
Infect Immun. 2005 Feb;73(2):1187-90. doi: 10.1128/IAI.73.2.1187-1190.2005.
Abstract
Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.
摘要
嗜吞噬细胞无形体感染会引起中性粒细胞功能改变。我们使用白色念珠菌和荧光聚集体吞噬试验，检测了嗜吞噬细胞无形体感染中性粒细胞及二甲基亚砜分化的HL-60细胞是否会损害内化作用。与对照组相比，嗜吞噬细胞无形体感染显著降低了吞噬作用（P < 0.05）。中性粒细胞功能的这种进一步损害可能会促进机会性感染并加重疾病。
相似文献
1
Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils.嗜吞噬细胞无形体感染的中性粒细胞中吞噬作用存在缺陷。
Infect Immun. 2005 Feb;73(2):1187-90. doi: 10.1128/IAI.73.2.1187-1190.2005.
2
Anaplasma phagocytophilum infection induces protracted neutrophil degranulation.嗜吞噬细胞无形体感染会引发持续性中性粒细胞脱颗粒。
Infect Immun. 2004 Jun;72(6):3680-3. doi: 10.1128/IAI.72.6.3680-3683.2004.
3
Anaplasma phagocytophilum infection reduces expression of phagocytosis-related receptors on neutrophils.嗜吞噬细胞无形体感染会降低中性粒细胞上吞噬作用相关受体的表达。
Ann N Y Acad Sci. 2005 Dec;1063:416-9. doi: 10.1196/annals.1355.075.
4
Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils.对病原体免疫逃避机制的见解：嗜吞噬细胞无形体无法在人类中性粒细胞中诱导凋亡分化程序。
J Immunol. 2005 May 15;174(10):6364-72. doi: 10.4049/jimmunol.174.10.6364.
5
Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin.嗜吞噬细胞无形体感染的中性粒细胞与内皮细胞的黏附力降低与白细胞表面选择素表达减少有关。
Infect Immun. 2003 Aug;71(8):4586-94. doi: 10.1128/IAI.71.8.4586-4594.2003.
6
Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes.感染嗜吞噬细胞无形体激活中性粒细胞中的磷脂酰肌醇 3-激酶/Akt 和 NF-κB 生存途径。
Infect Immun. 2012 Apr;80(4):1615-23. doi: 10.1128/IAI.05219-11. Epub 2012 Jan 17.
7
Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection.嗜吞噬细胞无形体利用多种宿主逃避机制，在中性粒细胞感染期间挫败烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶介导的杀伤作用。
Infect Immun. 2004 Aug;72(8):4772-83. doi: 10.1128/IAI.72.8.4772-4783.2004.
8
Early induction and late abrogation of respiratory burst in A. phagocytophilum-infected neutrophils.嗜吞噬细胞无形体感染的中性粒细胞中呼吸爆发的早期诱导和晚期消除。
Ann N Y Acad Sci. 2003 Jun;990:488-93. doi: 10.1111/j.1749-6632.2003.tb07415.x.
9
Anaplasma phagocytophilum delay of neutrophil apoptosis through the p38 mitogen-activated protein kinase signal pathway.嗜吞噬细胞无形体通过p38丝裂原活化蛋白激酶信号通路延迟中性粒细胞凋亡。
Infect Immun. 2005 Dec;73(12):8209-18. doi: 10.1128/IAI.73.12.8209-8218.2005.
10
Neutrophil NADPH oxidase is reduced at the Anaplasma phagocytophilum phagosome.嗜吞噬细胞无形体吞噬体处的中性粒细胞NADPH氧化酶减少。
Infect Immun. 2004 Sep;72(9):5392-401. doi: 10.1128/IAI.72.9.5392-5401.2004.
引用本文的文献
1
Temporal patterns of gene expression in response to inoculation with a virulent Anaplasma phagocytophilum strain in sheep.绵羊接种毒力强的细胞内寄生菌后基因表达的时间模式。
Sci Rep. 2023 Nov 21;13(1):20399. doi: 10.1038/s41598-023-47801-6.
2
Innate immunity in rickettsial infections.立克次体感染中的固有免疫。
Front Cell Infect Microbiol. 2023 May 9;13:1187267. doi: 10.3389/fcimb.2023.1187267. eCollection 2023.
3
Activates NF-κB Signaling via Redundant Pathways.通过冗余途径激活 NF-κB 信号。
Front Public Health. 2020 Oct 30;8:558283. doi: 10.3389/fpubh.2020.558283. eCollection 2020.
4
infection in cats: A literature review to raise clinical awareness.猫感染：提高临床认识的文献综述。
J Feline Med Surg. 2020 May;22(5):428-441. doi: 10.1177/1098612X20917600.
5
Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan.金门岛人体粒细胞无形体病。
PLoS Negl Trop Dis. 2019 Sep 20;13(9):e0007728. doi: 10.1371/journal.pntd.0007728. eCollection 2019 Sep.
6
Alternative Splicing of Differentiated Myeloid Cell Transcripts after Infection by Impacts a Selective Group of Cellular Programs.感染后分化的髓样细胞转录本的可变剪接影响了一组特定的细胞程序。
Front Cell Infect Microbiol. 2018 Feb 2;8:14. doi: 10.3389/fcimb.2018.00014. eCollection 2018.
7
Genome-Wide AnkA-DNA Interactions Are Enriched in Intergenic Regions and Gene Promoters and Correlate with Infection-Induced Differential Gene Expression.全基因组AnkA-DNA相互作用在基因间区域和基因启动子中富集，并与感染诱导的差异基因表达相关。
Front Cell Infect Microbiol. 2016 Sep 20;6:97. doi: 10.3389/fcimb.2016.00097. eCollection 2016.
8
Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils.嗜吞噬细胞无形体感染的人类中性粒细胞中的全基因组DNA甲基化变化及基因表达差异
Clin Epigenetics. 2015 Jul 29;7(1):77. doi: 10.1186/s13148-015-0105-1. eCollection 2015.
9
Chromatin-bound bacterial effector ankyrin A recruits histone deacetylase 1 and modifies host gene expression.染色质结合细菌效应物锚蛋白 A 招募组蛋白去乙酰化酶 1 并修饰宿主基因表达。
Cell Microbiol. 2015 Nov;17(11):1640-52. doi: 10.1111/cmi.12461. Epub 2015 Jun 11.
10
Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure.效应器瓶颈：通过染色质结构的表观遗传重塑，微生物对寄生宿主细胞转录进行重新编程。
Front Genet. 2014 Aug 14;5:274. doi: 10.3389/fgene.2014.00274. eCollection 2014.
本文引用的文献
1
CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis.在人类粒细胞无形体病小鼠模型中，CXCR2阻断影响嗜吞噬细胞无形体的繁殖，但不影响组织病理学。
Clin Diagn Lab Immunol. 2004 Sep;11(5):963-8. doi: 10.1128/CDLI.11.5.963-968.2004.
2
Anaplasma phagocytophilum infection induces protracted neutrophil degranulation.嗜吞噬细胞无形体感染会引发持续性中性粒细胞脱颗粒。
Infect Immun. 2004 Jun;72(6):3680-3. doi: 10.1128/IAI.72.6.3680-3683.2004.
3
Divergent interactions of Ehrlichia chaffeensis- and Anaplasma phagocytophilum-infected leukocytes with endothelial cell barriers.恰菲埃立克体和嗜吞噬细胞无形体感染的白细胞与内皮细胞屏障的不同相互作用。
Infect Immun. 2003 Dec;71(12):6728-33. doi: 10.1128/IAI.71.12.6728-6733.2003.
4
Regulation of the neutrophil-mediated inflammatory response to infection.中性粒细胞介导的感染炎症反应的调节。
Microbes Infect. 2003 Nov;5(14):1337-44. doi: 10.1016/j.micinf.2003.09.013.
5
Phagocytosis by neutrophils.
Microbes Infect. 2003 Nov;5(14):1299-306. doi: 10.1016/j.micinf.2003.09.014.
6
Invasion and survival strategies of Anaplasma phagocytophilum.嗜吞噬细胞无形体的侵袭与生存策略
Cell Microbiol. 2003 Nov;5(11):743-54. doi: 10.1046/j.1462-5822.2003.00323.x.
7
The effect of thick-borne fever on the resistance of lambs to staphylococci.厚积热对羔羊抗葡萄球菌能力的影响。
J Comp Pathol. 1956 Jul;66(3):278-85. doi: 10.1016/s0368-1742(56)80029-5.
8
Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin.嗜吞噬细胞无形体感染的中性粒细胞与内皮细胞的黏附力降低与白细胞表面选择素表达减少有关。
Infect Immun. 2003 Aug;71(8):4586-94. doi: 10.1128/IAI.71.8.4586-4594.2003.
9
Early induction and late abrogation of respiratory burst in A. phagocytophilum-infected neutrophils.嗜吞噬细胞无形体感染的中性粒细胞中呼吸爆发的早期诱导和晚期消除。
Ann N Y Acad Sci. 2003 Jun;990:488-93. doi: 10.1111/j.1749-6632.2003.tb07415.x.
10
Infection exclusion of the rickettsial pathogen anaplasma marginale in the tick vector Dermacentor variabilis.蜱媒变异革蜱中边缘无形体立克次体病原体的感染排除
Clin Diagn Lab Immunol. 2003 Jan;10(1):182-4. doi: 10.1128/cdli.10.1.182-184.2003.
Zotero 插件