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1
Prevalence of the hifBC, hmw1A, hmw2A, hmwC, and hia Genes in Haemophilus influenzae Isolates.流感嗜血杆菌分离株中hifBC、hmw1A、hmw2A、hmwC和hia基因的流行情况。
J Clin Microbiol. 2004 Jul;42(7):3065-72. doi: 10.1128/JCM.42.7.3065-3072.2004.
2
Evolutionary and functional relationships among the nontypeable Haemophilus influenzae HMW family of adhesins.不可分型流感嗜血杆菌高分子量黏附素家族之间的进化和功能关系。
J Bacteriol. 2004 Jul;186(13):4209-17. doi: 10.1128/JB.186.13.4209-4217.2004.
3
The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis.流感嗜血杆菌HMW1黏附素在一个需要HMW1C和磷酸葡萄糖变位酶（一种参与脂寡糖生物合成的酶）的过程中发生糖基化。
Mol Microbiol. 2003 May;48(3):737-51. doi: 10.1046/j.1365-2958.2003.03450.x.
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Prevalence and distribution of adhesins in invasive non-type b encapsulated Haemophilus influenzae.侵袭性非b型包膜流感嗜血杆菌中黏附素的流行情况及分布
Infect Immun. 2003 Apr;71(4):1635-42. doi: 10.1128/IAI.71.4.1635-1642.2003.
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Mapping of binding domains of nontypeable Haemophilus influenzae HMW1 and HMW2 adhesins.不可分型流感嗜血杆菌HMW1和HMW2黏附素结合结构域的定位
Infect Immun. 2001 Jan;69(1):307-14. doi: 10.1128/IAI.69.1.307-314.2001.
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Characterization of adherence of nontypeable Haemophilus influenzae to human epithelial cells.不可分型流感嗜血杆菌对人上皮细胞黏附特性的研究
Infect Immun. 2000 Aug;68(8):4658-65. doi: 10.1128/IAI.68.8.4658-4665.2000.
7
Maturation and secretion of the non-typable Haemophilus influenzae HMW1 adhesin: roles of the N-terminal and C-terminal domains.不可分型流感嗜血杆菌HMW1黏附素的成熟与分泌：N端和C端结构域的作用
Mol Microbiol. 2000 Apr;36(1):55-67. doi: 10.1046/j.1365-2958.2000.01812.x.
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Variation in expression of the Haemophilus influenzae HMW adhesins: a prokaryotic system reminiscent of eukaryotes.流感嗜血杆菌高分子量黏附素表达的变异：一个类似于真核生物的原核系统。
Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1077-82. doi: 10.1073/pnas.96.3.1077.
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Adhesin expression in matched nasopharyngeal and middle ear isolates of nontypeable Haemophilus influenzae from children with acute otitis media.急性中耳炎患儿不可分型流感嗜血杆菌鼻咽部和中耳分离株中黏附素的表达
Infect Immun. 1999 Jan;67(1):449-54. doi: 10.1128/IAI.67.1.449-454.1999.
10
Immunologic and structural relationships of the minor pilus subunits among Haemophilus influenzae isolates.流感嗜血杆菌分离株中小菌毛亚基的免疫学和结构关系。
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从不可分型流感嗜血杆菌中鉴定新的hmwA等位基因。

Identification of new hmwA alleles from nontypeable Haemophilus influenzae.

作者信息

Ecevit I Zafer, McCrea Kirk W, Marrs Carl F, Gilsdorf Janet R

机构信息

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109-0244, USA.

出版信息

Infect Immun. 2005 Feb;73(2):1221-5. doi: 10.1128/IAI.73.2.1221-1225.2005.

DOI:10.1128/IAI.73.2.1221-1225.2005
PMID:15664969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC546938/
Abstract

High-molecular-weight proteins of Haemophilus influenzae mediate attachment to epithelial cells. Previous reports describe several allelic versions of hmwA genes that have different adherence properties. Here we report three new alleles of hmwA (hmwA from strain AAr96, hmwA from strain AAr105, and hmwA from strain G822), demonstrating the high degree of DNA variation of these genes among different strains.

摘要

流感嗜血杆菌的高分子量蛋白介导其与上皮细胞的附着。先前的报道描述了几种具有不同黏附特性的hmwA基因的等位基因变体。在此，我们报告了hmwA的三个新等位基因（来自菌株AAr96的hmwA、来自菌株AAr105的hmwA和来自菌株G822的hmwA），证明了这些基因在不同菌株间存在高度的DNA变异。