Tang Y, Saif Y M
Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA.
Avian Dis. 2004 Dec;48(4):896-901. doi: 10.1637/7169-021904R.
Astroviruses are positive-sense single-stranded RNA viruses. These viruses cause gastroenteritis in humans and in a variety of animal species, including turkey poults. Only human astroviruses are well characterized antigenically. In the current study, two turkey astrovirus isolates, TAstV1987 and TAstV2001, were antigenically compared using cross-neutralization tests in turkey embryos, as well as cross-reactivity of the two isolates by an enzyme-linked immunosorbent assay (ELISA). The antigenic relatedness values (R) were calculated using the Archetti and Horsfall formula. The R value based on the cross-neutralization tests was 0.56%, which indicates that TAstV1987 and TAstV2001 belong to different serotypes; the R value of the two viruses based on ELISA was 70.7%, which suggests these two viruses share common antigen(s).
星状病毒是正链单链RNA病毒。这些病毒可导致人类以及包括小火鸡在内的多种动物物种患肠胃炎。只有人类星状病毒在抗原方面有充分的特征描述。在当前研究中，使用火鸡胚胎中的交叉中和试验对抗两种火鸡星状病毒分离株TAstV1987和TAstV2001的抗原性，并通过酶联免疫吸附测定（ELISA）检测这两种分离株的交叉反应性。使用Archetti和Horsfall公式计算抗原相关性值（R）。基于交叉中和试验的R值为0.56%，这表明TAstV1987和TAstV2001属于不同血清型；基于ELISA的两种病毒的R值为70.7%，这表明这两种病毒有共同抗原。
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