Singh Ashvind N, Matson Johnny L, Cooper Christopher L, Dixon Dennis, Sturmey Peter
Department of Psychology, Louisiana State University, Baton Rouge, LA, USA.
Res Dev Disabil. 2005 May-Jun;26(3):203-18. doi: 10.1016/j.ridd.2004.07.001.
Since their introduction, antipsychotic medications have been used widely to treat conditions other than psychiatric disorders, especially among individuals with mental retardation. Researchers have shown that the prevalence rates of psychotropic medication prescriptions among this population are extremely high. Given the limited empirical data to support the use of psychotropic medications, specifically antipsychotics, among individuals with mental retardation, this trend is a cause for concern. This review was undertaken in an effort to summarize the available studies regarding the use of the atypical antipsychotic drug risperidone among individuals with mental retardation and provide a resource for clinicians, care givers, and parents. Based on the results of this review, the effectiveness of risperidone in targeting psychopathology and challenging behaviors for individuals with mental retardation is questionable at present.
自抗精神病药物问世以来，它们被广泛用于治疗精神疾病以外的病症，尤其是在智力障碍患者中。研究人员表明，这一人群中精神药物处方的患病率极高。鉴于支持在智力障碍患者中使用精神药物，特别是抗精神病药物的实证数据有限，这种趋势令人担忧。进行这项综述是为了总结关于在智力障碍患者中使用非典型抗精神病药物利培酮的现有研究，并为临床医生、护理人员和家长提供参考资料。基于这项综述的结果，目前利培酮针对智力障碍患者的精神病理学和挑战行为的有效性值得怀疑。
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