静脉快速注射丙戊酸治疗癫痫持续状态的疗效。

Efficacy of rapid IV administration of valproic acid for status epilepticus.

作者信息

Limdi N A, Shimpi A V, Faught E, Gomez C R, Burneo J G

机构信息

University of Alabama School of Medicine,Birmingham, AL, USA.

出版信息

Neurology. 2005 Jan 25;64(2):353-5. doi: 10.1212/01.WNL.0000149527.47600.5A.

DOI:10.1212/01.WNL.0000149527.47600.5A

PMID:15668440

Abstract

Although not approved by the US Food and Drug Administration for the treatment of status epilepticus (SE), valproic acid (VPA) is an emerging option for this purpose. The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose, 31.5 mg/kg). Analysis of demographic, clinical, and treatment information indicated an overall efficacy of 63.3% and favorable tolerance of rapid administration.

摘要

尽管丙戊酸（VPA）未被美国食品药品监督管理局批准用于治疗癫痫持续状态（SE），但它正成为用于此目的的一种新选择。作者回顾了63例接受静脉注射VPA治疗的SE患者（30名男性）。对人口统计学、临床和治疗信息的分析表明，总体有效率为63.3%，且快速给药耐受性良好。