Xu X J, Hao J X, Seiger A, Arnér S, Lindblom U, Wiesenfeld-Hallin Z
Department of Clinical Physiology, Huddinge University Hospital, Sweden.
Anesth Analg. 1992 May;74(5):649-52. doi: 10.1213/00000539-199205000-00005.
We have recently reported a chronic allodynialike symptom in rats after ischemic spinal cord injury. This pain-related behavior is resistant to a number of pharmacologic treatments, including morphine, clonidine, carbamazepine, baclofen, and muscimol. In the present report, we present evidence indicating that systemic mexiletine, a local anesthetic and antiarrhythmic agent, effectively relieves the allodynia-like symptoms at doses of 15 and 30 mg/kg in these rats without inducing major side effects. It is suggested that systemically applied mexiletine may be useful in treating central pain in patients with spinal cord injury.
我们最近报道了大鼠脊髓缺血性损伤后出现慢性痛觉过敏样症状。这种疼痛相关行为对多种药物治疗有抵抗性，包括吗啡、可乐定、卡马西平、巴氯芬和蝇蕈醇。在本报告中，我们提供的证据表明，全身性应用美西律（一种局部麻醉药和抗心律失常药），在剂量为15和30mg/kg时可有效缓解这些大鼠的痛觉过敏样症状，且不会引起主要副作用。提示全身性应用美西律可能对治疗脊髓损伤患者的中枢性疼痛有用。
