Hu Aiguo, Lin Wenbin
Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA.
Org Lett. 2005 Feb 3;7(3):455-8. doi: 10.1021/ol0474812.
[reaction: see text] A family of tunable precatalysts [NH2Et2][{Ru(4,4'-BINAP)Cl}2(mu-Cl)3] was synthesized and used for highly enantioselective hydrogenation of phthalimide-protected amino ketones and 1,3-diaryldiketones. The bulky groups on the 4,4'-positions of BINAP were believed to be responsible for the enhancement of enantioselectivity (and diasteroselectivity) in these reactions.
[反应：见正文] 合成了一系列可调变的预催化剂[NH2Et2][{Ru(4,4'-联萘二苯膦)Cl}2(μ-Cl)3]，并将其用于邻苯二甲酰亚胺保护的氨基酮和1,3-二芳基二酮的高度对映选择性氢化反应。BINAP的4,4'-位上的庞大基团被认为是这些反应中对映选择性（和非对映选择性）提高的原因。
