西班牙一家大型教学医院中艰难梭菌的产毒状态

Toxigenic status of Clostridium difficile in a large Spanish teaching hospital.

作者信息

Alonso R, Martín A, Peláez T, Marín M, Rodríguez-Creixéms M, Bouza E

机构信息

Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario ''Gregorio Marañón'', C/Doctor Esquerdo, 46, 28007 Madrid, Spain.

出版信息

J Med Microbiol. 2005 Feb;54(Pt 2):159-162. doi: 10.1099/jmm.0.45809-0.

DOI:10.1099/jmm.0.45809-0

PMID:15673510

Abstract

The aim of this study was to evaluate the toxigenic status of circulating strains of Clostridium difficile in a large teaching hospital. Overall 220 isolates were studied of which 199 (90.5 %) produced both large clostridial toxins detected by conventional methods. Ten more strains (4.5 %) had toxin A and B genes detectable by PCR. Eleven (5.0 %) variant strains (A- B+) were detected among the isolates studied and 10 strains (4.5 %) had the binary toxin genes (cdtA and cdtB).

摘要

本研究的目的是评估一家大型教学医院中艰难梭菌流行菌株的产毒状况。总共研究了220株分离株，其中199株（90.5%）通过传统方法检测出产生两种大梭菌毒素。另有10株（4.5%）通过PCR检测到毒素A和B基因。在所研究的分离株中检测到11株（5.0%）变异株（A - B+），10株（4.5%）含有二元毒素基因（cdtA和cdtB）。