在波兰从艰难梭菌相关性腹泻（CDAD）患者中分离出的艰难梭菌菌株中检测二元毒素基因（cdtA和cdtB）。
Detection of binary-toxin genes (cdtA and cdtB) among Clostridium difficile strains isolated from patients with C. difficile-associated diarrhoea (CDAD) in Poland.
作者信息
Pituch Hanna, Rupnik Maja, Obuch-Woszczatyński Piotr, Grubesic Ana, Meisel-Mikołajczyk Felicja, Łuczak Mirosław
机构信息
Department of Medical Microbiology, Medical University of Warsaw, 5 Chalubinski Street, 02-004 Warsaw, Poland 2Department of Biology, University of Ljubljana, Ljubljana, Slovenia.
出版信息
J Med Microbiol. 2005 Feb;54(Pt 2):143-147. doi: 10.1099/jmm.0.45799-0.
Clostridium difficile A+ B+ and A- B+ strains isolated from stool samples of patients with C. difficile-associated diarrhoea (CDAD) were selected from the University Hospital Warsaw collection. The binary-toxin genes cdtA and cdtB were detected by PCR in five of the 41 A+ B+ strains tested, but in none of the 17 A- B+ strains tested, giving 8.6 % prevalence (5/58) of binary-toxin-positive strains. All of the strains that were positive for binary-toxin genes were grouped into toxinotype IV, suggesting that in this institution toxinotype IV might dominate among the population of C. difficile with binary-toxin genes.
从华沙大学医院收集的艰难梭菌相关性腹泻（CDAD）患者粪便样本中分离出艰难梭菌A + B +和A - B +菌株。在检测的41株A + B +菌株中，有5株通过PCR检测到二元毒素基因cdtA和cdtB，但在检测的17株A - B +菌株中均未检测到，二元毒素阳性菌株的患病率为8.6%（5/58）。所有二元毒素基因呈阳性的菌株均归为毒素型IV，这表明在该机构中，具有二元毒素基因的艰难梭菌群体中可能以毒素型IV为主。
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