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早期脊柱固定对非神经学预后的影响。

The effect of early spine fixation on non-neurologic outcome.

作者信息

Kerwin Andrew J, Frykberg Eric R, Schinco Miren A, Griffen Margaret M, Murphy Terri, Tepas Joseph J

机构信息

University of Florida Health Science Center-Jacksonville, Department of Surgery, Division of Trauma and Critical Care, Jacksonville, Florida 32209, USA.

出版信息

J Trauma. 2005 Jan;58(1):15-21. doi: 10.1097/01.ta.0000154182.35386.7e.

Abstract

INTRODUCTION

It has been shown that spinal fracture fixation within 3 days can reduce the incidence of pneumonia, length of stay, number of ventilator days, and hospital charges. Our institutional protocol calls for surgical stabilization of spinal fractures within 3 days of admission. We hypothesized that compliance with an early spinal fracture fixation protocol (within 3 days of admission) would improve non-neurologic outcome in patients with spinal fractures.

METHODS

The trauma registry was queried for the period January 1988 through October 2001 to identify patients with spinal fractures requiring surgical stabilization. Patients were analyzed to determine the compliance with our protocol and to determine whether early spinal fixation can reduce the incidence of pneumonia, reduce length of stay, and reduce mortality.

RESULTS

1,741 patients with spinal fractures were identified. 299 (17.2%) required surgical stabilization. 174 (58.2%) had surgical stabilization within 3 days while 125 (41.8%) had surgical stabilization greater than 3 days from admission. There were no significant differences between the two groups with regards to age (37.9 versus 42.5), admission GCS (14.1 versus 13.9), or ISS (22 versus 20.8). The incidence of pneumonia was similar in both groups (21.8 versus 25.6%). The mortality was higher in the early group as compared with the late group (6.9 versus 2.5%), although it did not reach statistical significance. The hospital length of stay was significantly shorter (14.3 versus 21.1) for patients who had early spine fixation, however there was no statistically significant difference between the two groups with regards to intensive care unit length of stay (7.2 versus 7.9) or number of ventilator days (5.02 versus 1.9). Patients who were severely injured (ISS > 25) also had a significantly shorter hospital length of stay (19.6 versus 29.1) if they underwent early spinal fixation. Patients with thoracic spine injury and associated spinal cord injury had a significantly shorter HLOS (10.1 versus 30.5), ICULOS (2.3 versus 13.1), and lower incidence of pneumonia (6.5 versus 33.3%).

CONCLUSIONS

Reasonable compliance with an early spinal fracture fixation protocol produced some outcome improvements in non-neurologic outcome. Early spine stabilization reduced hospital length of stay in all patients. Patients with thoracic spine trauma and a spinal cord injury had the greatest benefit in reduction of morbidity, HLOS and ICULOS from early stabilization. There was a trend toward poorer outcome in some groups with early spine stabilization. A rigid protocol requiring early surgical spine stabilization in all patients does not appear justified. Although early spine stabilization should be performed whenever possible to reduce hospital length of stay, the timing of this procedure should be individualized to allow patients with the most severe physiologic derangements to be optimized preoperatively.

摘要

引言

研究表明,在3天内进行脊柱骨折固定可降低肺炎发生率、缩短住院时间、减少呼吸机使用天数及降低住院费用。我们机构的方案要求在入院3天内对脊柱骨折进行手术固定。我们假设,遵循早期脊柱骨折固定方案(入院3天内)可改善脊柱骨折患者的非神经学预后。

方法

查询1988年1月至2001年10月期间的创伤登记资料,以确定需要手术固定的脊柱骨折患者。对患者进行分析,以确定其对我们方案的依从性,并确定早期脊柱固定是否可降低肺炎发生率、缩短住院时间及降低死亡率。

结果

共确定1741例脊柱骨折患者。299例(17.2%)需要手术固定。174例(58.2%)在3天内进行了手术固定,而125例(41.8%)在入院3天后进行了手术固定。两组在年龄(37.9对42.5)、入院时格拉斯哥昏迷评分(14.1对13.9)或损伤严重度评分(22对20.8)方面无显著差异。两组肺炎发生率相似(21.8%对25.6%)。早期组的死亡率高于晚期组(6.9%对2.5%),尽管未达到统计学显著性。早期进行脊柱固定的患者住院时间显著缩短(14.3天对21.1天),然而两组在重症监护病房住院时间(7.2天对7.9天)或呼吸机使用天数(5.02天对1.9天)方面无统计学显著差异。严重受伤(损伤严重度评分>25)的患者若早期进行脊柱固定,其住院时间也显著缩短(19.6天对29.1天)。胸椎损伤并伴有脊髓损伤的患者住院时间、重症监护病房住院时间显著缩短(10.1天对30.5天,2.3天对13.1天),肺炎发生率较低(6.5%对33.3%)。

结论

合理遵循早期脊柱骨折固定方案可在非神经学预后方面带来一些改善。早期脊柱固定可缩短所有患者的住院时间。胸椎创伤并伴有脊髓损伤的患者从早期固定中在降低发病率、缩短住院时间和重症监护病房住院时间方面获益最大。在一些早期进行脊柱固定的组中存在预后较差的趋势。要求对所有患者进行早期脊柱手术固定的严格方案似乎不合理。尽管应尽可能早期进行脊柱固定以缩短住院时间,但该手术的时机应个体化,以使生理紊乱最严重的患者在术前得到优化。

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