Synthesis and antiparasitic properties of new 4-N-benzylamino-4-hetarylbut-1-enes.
作者信息
Kouznetsov Vladimir V, Castro Juliette Rivero, Puentes Cristian Ochoa, Stashenko Elena E, Martínez Jairo René, Ochoa Carmen, Pereira David Montero, Ruiz Juan J Nogal, Portillo Carlos Fernández, Serrano Susana Muelas, Barrio Alicia Gómez, Bahsas Alí, Amaro-Luis Juan
机构信息
Laboratory of Fine Organic Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, AA 678, Bucaramanga, Colombia.
出版信息
Arch Pharm (Weinheim). 2005 Jan;338(1):32-7. doi: 10.1002/ardp.200400909.
New derivatives of 4-N-benzylamino-4-hetarylbut-1-ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N-oxide derivatives were obtained from these homoallylamines. Study of the antiparasitic properties of obtained pyridine derivatives as well as of four related benzazepines previously described, was carried out using cytotoxicity assays against Trichomonas vaginalis and epimastigote form of Trypanosoma cruzi protozoa. Compounds showing activity against epimastigote T. cruzi were tested against the amastigote form; unspecific cytotoxicity against macrophages was also studied.
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