新型3,5-二取代-四氢-2H-1,3,5-噻二嗪-2-硫酮衍生物的合成及其抗原生动物特性

Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives.

作者信息

Ochoa C, Pérez E, Pérez R, Suárez M, Ochoa E, Rodríguez H, Gómez Barrio A, Muelas S, Nogal J J, Martínez R A

机构信息

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

出版信息

Arzneimittelforschung. 1999 Sep;49(9):764-9. doi: 10.1055/s-0031-1300499.

DOI:10.1055/s-0031-1300499

PMID:10514905

Abstract

In a search for antiprotozoan compounds, 34 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan activity. In vivo assays of compounds which showed remarkable in vitro activity against T. vaginalis were carried out.

摘要

为了寻找抗原生动物化合物，合成了34种新的3,5-二取代-四氢-2H-1,3,5-噻二嗪-2-硫酮衍生物，并对其进行体外抗克鲁斯锥虫和阴道毛滴虫试验。其中一些显示出重要的抗原生动物活性。对那些在体外对阴道毛滴虫显示出显著活性的化合物进行了体内试验。