Nelson R, Edwards S, Tse B
Surgery, University of Illinois, 1740 West Taylor, Room 2204 m/c 957, Chicago, Illinois 60612, USA.
Cochrane Database Syst Rev. 2005 Jan 25(1):CD004929. doi: 10.1002/14651858.CD004929.pub2.
Routine use of nasogastric tubes after abdominal operations is intended to hasten the return of bowel function, prevent pulmonary complications, diminish the risk of anastomotic leakage, increase patient comfort and shorten hospital stay.
To investigate the efficacy of routine nasogastric decompression after abdominal surgery in achieving each of the above goals.
Search terms were nasogastric, tubes, randomised, using MEDLINE, EMBASE, Cochrane Controlled Trials Register, and references of included studies.
Patients having abdominal operations of any type, emergency or elective, who were randomised prior tot he completion of the operation to receive a nasogastric tube and keep it in place until intestinal function had returned, versus those receiving either no tube or early tube removal, in surgery, in recovery or within 24 hours of surgery. Excluded will be randomised studies involving laparoscopic abdominal surgery and patient groups having gastric decompression through gastrostomy.
Data were abstracted onto a form that assessed study eligibility, as defined above, quality related to randomizations, allocation concealment, study size and dropouts, interventions, including timing and duration of intubation, outcomes that included time to flatus, pulmonary complications, wound infection, anastomotic leak, length of stay, death, nausea, vomiting, tube reinsertion, subsequent ventral hernia.
28 studies fulfilled eligibility criteria, encompassing 4194 patients, 2108 randomised to routine tube use, and 2087 randomised to selective or No Tube use. Patients not having routine tube use had an earlier return of bowel function (p<0.00001), an insignificant trend toward decrease in pulmonary complications (p=0.07) and an insignificant trend toward increase in risk of wound infection (p=0.08) and ventral hernia (0.09). Anastomotic leak was no different between groups (p=0.70). Patient comfort, nausea, vomiting and length of stay seemed to favour No Tube, but the heterogeneity encountered in these analyses make rigorous conclusion difficult to draw for these outcomes. No adverse events specifically related to tube insertion (direct tube trauma) were reported. Other outcomes were reported with insufficient frequency to be informative.
AUTHORS' CONCLUSIONS: Routine nasogastric decompression does not accomplish any of its intended goals and so should be abandoned in favour of selective use of the nasogastric tube.
腹部手术后常规使用鼻胃管旨在加速肠道功能恢复、预防肺部并发症、降低吻合口漏的风险、提高患者舒适度并缩短住院时间。
探讨腹部手术后常规鼻胃管减压在实现上述各项目标方面的疗效。
使用医学主题词表(MEDLINE)、荷兰医学文摘数据库(EMBASE)、Cochrane对照试验注册库以及纳入研究的参考文献,以“鼻胃管”“导管”“随机”作为检索词。
接受任何类型腹部手术(急诊或择期)的患者,在手术完成前被随机分组,一组接受鼻胃管并保留至肠道功能恢复,另一组在手术中、恢复过程中或术后24小时内不使用鼻胃管或早期拔除鼻胃管。排除涉及腹腔镜腹部手术的随机研究以及通过胃造口进行胃减压的患者组。
数据被录入一张表格,该表格评估研究的入选资格(如上所定义)、与随机化、分配隐藏、研究规模和失访相关的质量、干预措施(包括插管的时间和持续时间)、结局指标(包括排气时间、肺部并发症、伤口感染、吻合口漏、住院时间、死亡、恶心、呕吐、再次插管、随后发生腹疝)。
28项研究符合入选标准,涵盖了4194例患者,其中2108例被随机分配至常规使用鼻胃管组,2087例被随机分配至选择性使用或不使用鼻胃管组。未常规使用鼻胃管的患者肠道功能恢复更早(p<0.00001),肺部并发症有降低的趋势但不显著(p=0.07),伤口感染风险(p=0.08)和腹疝风险(p=0.09)有增加的趋势但不显著。两组间吻合口漏无差异(p=0.70)。患者舒适度、恶心、呕吐和住院时间似乎更倾向于不使用鼻胃管组,但这些分析中遇到的异质性使得难以就这些结局得出严格的结论。未报告与插管(直接导管创伤)具体相关的不良事件。其他结局报告的频率不足以提供信息。
常规鼻胃管减压未能实现其任何预期目标,因此应放弃常规使用,转而选择性使用鼻胃管。