Nelson R, Edwards S, Tse B
Northern General Hospital, Department of General Surgery, Herries Road, Sheffield, UK, S5 7AU.
Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD004929. doi: 10.1002/14651858.CD004929.pub3.
Routine use of nasogastric tubes after abdominal operations is intended to hasten the return of bowel function, prevent pulmonary complications, diminish the risk of anastomotic leakage, increase patient comfort and shorten hospital stay.
To investigate the efficacy of routine nasogastric decompression after abdominal surgery in achieving each of the above goals.
Search terms were nasogastric, tubes, randomised, using MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (Central), and references of included studies, from 1966 through 2006.
Patients having abdominal operations of any type, emergency or elective, who were randomised prior tot he completion of the operation to receive a nasogastric tube and keep it in place until intestinal function had returned, versus those receiving either no tube or early tube removal, in surgery, in recovery or within 24 hours of surgery. Excluded will be randomised studies involving laparoscopic abdominal surgery and patient groups having gastric decompression through gastrostomy.
Data were abstracted onto a form that assessed study eligibility, as defined above, quality related to randomizations, allocation concealment, study size and dropouts, interventions, including timing and duration of intubation, outcomes that included time to flatus, pulmonary complications, wound infection, anastomotic leak, length of stay, death, nausea, vomiting, tube reinsertion, subsequent ventral hernia.
33 studies fulfilled eligibility criteria, encompassing 5240 patients, 2628 randomised to routine tube use, and 2612 randomised to selective or No Tube use. Patients not having routine tube use had an earlier return of bowel function (p<0.00001), a decrease in pulmonary complications (p=0.01) and an insignificant trend toward increase in risk of wound infection (p=0.22) and ventral hernia (0.09). Anastomotic leak was no different between groups (p=0.70). Vomiting seemed to favour routine tube use, but with increased patient discomfort. Length of stay was shorter when no tube was used but the heterogeneity encountered in these analyses make rigorous conclusion difficult to draw for this outcome. No adverse events specifically related to tube insertion (direct tube trauma) were reported. Other outcomes were reported with insufficient frequency to be informative.
AUTHORS' CONCLUSIONS: Routine nasogastric decompression does not accomplish any of its intended goals and so should be abandoned in favour of selective use of the nasogastric tube.
腹部手术后常规使用鼻胃管旨在加速肠功能恢复、预防肺部并发症、降低吻合口漏的风险、增加患者舒适度并缩短住院时间。
探讨腹部手术后常规鼻胃管减压在实现上述各项目标方面的效果。
检索词为鼻胃管、导管、随机对照,使用MEDLINE、EMBASE、Cochrane对照试验中心注册库(CENTRAL)以及纳入研究的参考文献,检索时间为1966年至2006年。
接受任何类型腹部手术(急诊或择期)的患者,在手术完成前被随机分组,一组接受鼻胃管并保留至肠功能恢复,另一组在手术中、恢复过程中或术后24小时内不使用鼻胃管或早期拔除鼻胃管。排除涉及腹腔镜腹部手术的随机对照研究以及通过胃造口进行胃减压的患者组。
数据被录入一张表格,该表格评估研究的纳入标准,如上述定义,与随机化、分配隐藏、研究规模和失访相关的质量,干预措施,包括插管时间和持续时间,结局指标,包括排气时间、肺部并发症、伤口感染、吻合口漏、住院时间、死亡、恶心、呕吐、再次插管、随后发生的腹疝。
33项研究符合纳入标准,涵盖5240例患者,其中2628例被随机分配接受常规鼻胃管使用,2612例被随机分配接受选择性或不使用鼻胃管。未常规使用鼻胃管的患者肠功能恢复更早(p<0.00001),肺部并发症减少(p=0.01),伤口感染(p=0.22)和腹疝(p=0.09)风险增加的趋势不显著。两组间吻合口漏无差异(p=0.70)。呕吐似乎更倾向于常规使用鼻胃管,但患者不适感增加。不使用鼻胃管时住院时间更短,但这些分析中遇到的异质性使得难以就该结局得出严格结论。未报告与插管(直接导管创伤)具体相关的不良事件。其他结局报告的频率不足以提供信息。
常规鼻胃管减压未能实现其任何预期目标,因此应放弃常规使用,转而选择性使用鼻胃管。