Takami Masashi, Maruyama Aya, Fukai Hiroshi, Matsumoto Hiroshi, Togo Yoshichika, Takimoto Toshirou, Sakamoto Hideki, Yamamoto Tatsuo
Dept. of Obstetrics and Gynecology, Kasukabe Municipal General Hospital.
Gan To Kagaku Ryoho. 2005 Jan;32(1):103-6.
We report here a case of synchronous dermoid cyst with secondary malignant tumor and uterine endometrial adenocarcinoma that responded to UFT. A 35-year-old female complained of abdominal fullness and visited our hospital. She had an abdominal mass which was newborn-head size. We performed right salpingo-oophorectomy and partial omentectomy. The pathological findings were dermoid cyst with secondary malignant transformation. After the operation she had underwent cyclic chemotherapy with CDDP, CPA, THP and 5-FU. After three cycles of chemotherapy, a uterine recurrence was suspected from her uterine endocervical smear test. Then we performed a second operation, but radical surgery was impossible due to the presence of multiple metastases to pelvic lymph nodes. The pathological findings were primary uterine endometrial adenocarcinoma, not metastasis from dermoid cyst with secondary malignant tumor. After the second operation, she was treated with oral UFT (400 mg/day), as she refused chemotherapy and radiotherapy. Two months after the start of UFT, the tumor markers were reduced remarkably, and the patient maintained good QOL throughout the treatment without serious adverse events. We conclude that UFT might be benefical in the treatment of advanced gynecologic cancer.
我们在此报告一例同步存在皮样囊肿伴继发性恶性肿瘤及子宫内膜腺癌且对优福定（UFT）有反应的病例。一名35岁女性因腹部胀满前来我院就诊。她有一个新生儿头大小的腹部肿块。我们进行了右侧输卵管卵巢切除术和部分大网膜切除术。病理结果为皮样囊肿伴继发性恶变。术后她接受了顺铂（CDDP）、环磷酰胺（CPA）、吡柔比星（THP）和氟尿嘧啶（5-FU）的周期性化疗。化疗三个周期后，通过子宫颈涂片检查怀疑子宫复发。随后我们进行了第二次手术，但由于盆腔淋巴结存在多处转移，无法进行根治性手术。病理结果为原发性子宫内膜腺癌，而非皮样囊肿伴继发性恶性肿瘤的转移。第二次手术后，由于她拒绝化疗和放疗，故接受口服优福定（400毫克/天）治疗。开始服用优福定两个月后，肿瘤标志物显著降低，且患者在整个治疗过程中生活质量良好，未出现严重不良事件。我们得出结论，优福定可能对晚期妇科癌症的治疗有益。
