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1型糖尿病成年人群和可比普通人群中的高血压患病率、知晓率、治疗率及控制率。

Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general population.

作者信息

Maahs David M, Kinney Gregory L, Wadwa Paul, Snell-Bergeon Janet K, Dabelea Dana, Hokanson John, Ehrlich James, Garg Satish, Eckel Robert H, Rewers Marian J

机构信息

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave., Denver, CO 80262, USA.

出版信息

Diabetes Care. 2005 Feb;28(2):301-6. doi: 10.2337/diacare.28.2.301.

Abstract

OBJECTIVE

To compare the prevalence, awareness, treatment, and control of hypertension in a population-representative sample of adults with type 1 diabetes and comparable nondiabetic control subjects.

RESEARCH DESIGN AND METHODS

In 2000-2002, the Coronary Artery Calcification in Type 1 Diabetes Study enrolled 1,416 individuals aged 19-56 years with no known history of coronary artery disease: 652 type 1 diabetic patients (46% male, mean age 37 years) and 764 nondiabetic control subjects (50% male, mean age 39 years). Subjects were asked if they had been told by a physician that they had hypertension or were on a blood pressure medication. Blood pressure was measured using standardized Joint National Committee (JNC) protocol.

RESULTS

Type 1 diabetic subjects, compared with nondiabetic subjects, had higher rates of hypertension prevalence (43 vs. 15%, P < 0.001), awareness (53 vs. 45%, P = 0.11), treatment (87 vs. 47%, P < 0.001), and control (55 vs. 32%, P < 0.001) for the JNC 6 goal (130/85 mmHg). Only 42% of all type 1 diabetic hypertensive subjects met the new JNC 7 goal (130/80 mmHg). Type 1 diabetic subjects had better blood pressure control (72 vs. 32%, P < 0.0001), using 140/90 mmHg as a common measure. The majority of treated subjects were on a single antihypertensive agent (75 vs. 64%).

CONCLUSIONS

Subjects with type 1 diabetes have higher rates of hypertension prevalence, treatment, and control than nondiabetic subjects. However, hypertension remains largely uncontrolled, even if treated in high-risk populations, such as type 1 diabetic subjects and undiagnosed individuals in the general population. Achieving more stringent blood pressure goals will require increased attention and may necessitate the use of multiple antihypertensive agents.

摘要

目的

比较1型糖尿病成年患者与非糖尿病对照人群中高血压的患病率、知晓率、治疗率和控制率。

研究设计与方法

在2000 - 2002年,1型糖尿病冠状动脉钙化研究纳入了1416名年龄在19 - 56岁、无已知冠状动脉疾病史的个体:652名1型糖尿病患者(46%为男性,平均年龄37岁)和764名非糖尿病对照者(50%为男性,平均年龄39岁)。询问受试者是否曾被医生告知患有高血压或正在服用降压药物。采用标准化的美国国家联合委员会(JNC)方案测量血压。

结果

与非糖尿病受试者相比,1型糖尿病受试者的高血压患病率(43%对15%,P < 0.001)、知晓率(53%对45%,P = 0.11)、治疗率(87%对47%,P < 0.001)和控制率(55%对32%,P < 0.001)更高,JNC 6目标为(130/85 mmHg)。所有1型糖尿病高血压受试者中只有42%达到新的JNC 7目标(130/80 mmHg)。以140/90 mmHg作为常用指标,1型糖尿病受试者的血压控制更好(72%对32%,P < 0.0001)。大多数接受治疗的受试者使用单一降压药物(75%对64%)。

结论

1型糖尿病患者的高血压患病率、治疗率和控制率高于非糖尿病患者。然而,即使在高危人群(如1型糖尿病患者和普通人群中未被诊断的个体)中进行治疗,高血压仍在很大程度上未得到控制。实现更严格的血压目标需要更多关注,可能需要使用多种降压药物。

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