Maahs David M, Kinney Gregory L, Wadwa Paul, Snell-Bergeon Janet K, Dabelea Dana, Hokanson John, Ehrlich James, Garg Satish, Eckel Robert H, Rewers Marian J
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave., Denver, CO 80262, USA.
Diabetes Care. 2005 Feb;28(2):301-6. doi: 10.2337/diacare.28.2.301.
To compare the prevalence, awareness, treatment, and control of hypertension in a population-representative sample of adults with type 1 diabetes and comparable nondiabetic control subjects.
In 2000-2002, the Coronary Artery Calcification in Type 1 Diabetes Study enrolled 1,416 individuals aged 19-56 years with no known history of coronary artery disease: 652 type 1 diabetic patients (46% male, mean age 37 years) and 764 nondiabetic control subjects (50% male, mean age 39 years). Subjects were asked if they had been told by a physician that they had hypertension or were on a blood pressure medication. Blood pressure was measured using standardized Joint National Committee (JNC) protocol.
Type 1 diabetic subjects, compared with nondiabetic subjects, had higher rates of hypertension prevalence (43 vs. 15%, P < 0.001), awareness (53 vs. 45%, P = 0.11), treatment (87 vs. 47%, P < 0.001), and control (55 vs. 32%, P < 0.001) for the JNC 6 goal (130/85 mmHg). Only 42% of all type 1 diabetic hypertensive subjects met the new JNC 7 goal (130/80 mmHg). Type 1 diabetic subjects had better blood pressure control (72 vs. 32%, P < 0.0001), using 140/90 mmHg as a common measure. The majority of treated subjects were on a single antihypertensive agent (75 vs. 64%).
Subjects with type 1 diabetes have higher rates of hypertension prevalence, treatment, and control than nondiabetic subjects. However, hypertension remains largely uncontrolled, even if treated in high-risk populations, such as type 1 diabetic subjects and undiagnosed individuals in the general population. Achieving more stringent blood pressure goals will require increased attention and may necessitate the use of multiple antihypertensive agents.
比较1型糖尿病成年患者与非糖尿病对照人群中高血压的患病率、知晓率、治疗率和控制率。
在2000 - 2002年,1型糖尿病冠状动脉钙化研究纳入了1416名年龄在19 - 56岁、无已知冠状动脉疾病史的个体:652名1型糖尿病患者(46%为男性,平均年龄37岁)和764名非糖尿病对照者(50%为男性,平均年龄39岁)。询问受试者是否曾被医生告知患有高血压或正在服用降压药物。采用标准化的美国国家联合委员会(JNC)方案测量血压。
与非糖尿病受试者相比,1型糖尿病受试者的高血压患病率(43%对15%,P < 0.001)、知晓率(53%对45%,P = 0.11)、治疗率(87%对47%,P < 0.001)和控制率(55%对32%,P < 0.001)更高,JNC 6目标为(130/85 mmHg)。所有1型糖尿病高血压受试者中只有42%达到新的JNC 7目标(130/80 mmHg)。以140/90 mmHg作为常用指标,1型糖尿病受试者的血压控制更好(72%对32%,P < 0.0001)。大多数接受治疗的受试者使用单一降压药物(75%对64%)。
1型糖尿病患者的高血压患病率、治疗率和控制率高于非糖尿病患者。然而,即使在高危人群(如1型糖尿病患者和普通人群中未被诊断的个体)中进行治疗,高血压仍在很大程度上未得到控制。实现更严格的血压目标需要更多关注,可能需要使用多种降压药物。