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转诊诊所与初级保健诊所中II型糖尿病患者的高血压患病率。

Prevalence of hypertension in patients with type II diabetes in referral versus primary care clinics.

作者信息

Moore W V, Fredrickson D, Brenner A, Childs B, Tatpati O, Hoffman J M, Guthrie R

机构信息

Robert L. Jackson Diabetes Center, Via Christi Medical Center, Wichita, Kansas 67211, USA.

出版信息

J Diabetes Complications. 1998 Nov-Dec;12(6):302-6. doi: 10.1016/s1056-8727(98)00009-9.

DOI:10.1016/s1056-8727(98)00009-9
PMID:9877462
Abstract

We compared the prevalence of hypertension in patients with non-insulin-dependent diabetes mellitus (NIDDM) in referral and primary care practices using definitions of The Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC-V), while controlling for other risk factors such as hypertension, obesity, smoking, and age. Patients (n = 1443) were enrolled consecutively from a large referral practice at the Jackson Diabetes Center and four primary care clinics in the vicinity. Blood pressures were measured at three clinic visits after a 5-min rest in a sitting position using a standard clinical sphygmomanometer. Charts were reviewed to determine diabetes duration, insulin usage, height, weight, smoking history, use of antihypertensive and oral hypoglycemic medications, socioeconomic status, and race. Patients were classified as hypertensive based on JNC-V definitions or if they were on antihypertensive medication. Hypertension was termed uncontrolled if blood pressure was JNC-V Stage 2 or higher while on antihypertensive medication. Seventy-eight percent of referral clinic and 55% of primary care clinic patients had either JNC-V State 1 or higher hypertension or were on antihypertensive medication. Actual blood pressures indicated that more patients had JNC-V Stage 1 (mild) or higher hypertension in referral compared to primary care clinics (62% versus 48% p = 0.01) but fewer had JNC-V Stage 2 or higher (moderate-severe) hypertension (12% versus 19% p = 0.002). Patients seen in the referral clinic were significantly more likely to have greater age, greater duration of diabetes, higher insulin dosage, longer smoking history, antihypertensive medication, and live outside the metropolitan area. By logistic regression, the odds of hypertension were significantly increased with age (OR 1.51/decade), BMI greater than 27 (OR 2.17), diabetes duration (OR 1.04/year), and insulin dosage (OR 1.74/U/kg). Current smoking and attending a referral clinic were not significantly related. The odds of moderate-severe hypertension were significantly increased with age (OR 1.23/ decade), decreased by attending a referral clinic (OR 0.45), and not significantly related to other confounders in the model. The prevalence of hypertension among patients with NIDDM was higher in referral than primary care clinics. The higher prevalence in the referral practice can be accounted for by the greater severity of associated risk factors in the referral practice patients; however, most patients will be diagnosed and treated for hypertension prior to referral. More patients in the referral practice were on hypertensive medication, which lowered the stage or severity of hypertension but still not to the normal range. The results suggest that the primary detection of hypertension in patients with type II diabetes resides with the primary care physician. Management of hypertension will require both a delineation and acceptance of responsibilities between the primary care physician and diabetes specialists.

摘要

我们使用美国国家联合委员会关于高血压检测、评估和治疗的第五次报告(JNC-V)的定义,在转诊和初级保健机构中比较了非胰岛素依赖型糖尿病(NIDDM)患者的高血压患病率,同时控制其他风险因素,如高血压、肥胖、吸烟和年龄。患者(n = 1443)连续从杰克逊糖尿病中心的大型转诊机构和附近的四家初级保健诊所招募。使用标准临床血压计,患者在坐位休息5分钟后,在三次门诊就诊时测量血压。查阅病历以确定糖尿病病程、胰岛素使用情况、身高、体重、吸烟史、抗高血压和口服降糖药物的使用、社会经济状况和种族。根据JNC-V定义或正在服用抗高血压药物,将患者分类为高血压患者。如果在服用抗高血压药物时血压处于JNC-V 2期或更高,则称高血压未得到控制。转诊诊所78%的患者和初级保健诊所55%的患者患有JNC-V 1期或更高的高血压,或者正在服用抗高血压药物。实际血压表明,与初级保健诊所相比,转诊诊所中患有JNC-V 1期(轻度)或更高高血压的患者更多(62%对48%,p = 0.01),但患有JNC-V 2期或更高(中度至重度)高血压的患者更少(12%对19%,p = 0.002)。在转诊诊所就诊的患者明显更有可能年龄更大、糖尿病病程更长、胰岛素剂量更高、吸烟史更长、服用抗高血压药物,并且居住在大都市区以外。通过逻辑回归分析,高血压的几率随着年龄(OR 1.51/十年)、BMI大于27(OR 2.17)、糖尿病病程(OR 1.04/年)和胰岛素剂量(OR 1.74/U/kg)显著增加。当前吸烟和在转诊诊所就诊与高血压无显著相关性。中度至重度高血压的几率随着年龄(OR 1.23/十年)显著增加,在转诊诊所就诊可使其降低(OR 0.45),并且与模型中的其他混杂因素无显著相关性。NIDDM患者中高血压的患病率在转诊诊所高于初级保健诊所。转诊机构中较高的患病率可归因于转诊机构患者中相关风险因素的严重性更高;然而,大多数患者在转诊前将被诊断并接受高血压治疗。转诊机构中有更多患者正在服用抗高血压药物,这降低了高血压的分期或严重程度,但仍未降至正常范围。结果表明,II型糖尿病患者高血压的初步检测应由初级保健医生负责。高血压的管理将需要初级保健医生和糖尿病专家明确并承担各自的责任。

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