慢性肾衰竭及持续性非卧床腹膜透析患者的血浆白细胞介素-18水平

Plasma interleukin-18 levels in chronic renal failure and continuous ambulatory peritoneal dialysis.

作者信息

Chiang Chih-Kang, Hsu Shih-Ping, Pai Mei-Fen, Peng Yu-Sen, Ho Tai-I, Liu Shing-Hwa, Hung Kuan-Yu, Tsai Tun-Jun, Hsieh Bor-Shen

机构信息

Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.

出版信息

Blood Purif. 2005;23(2):144-8. doi: 10.1159/000083620. Epub 2005 Jan 25.

DOI:10.1159/000083620

PMID:15677863

Abstract

BACKGROUND/AIMS: Based on associations of interleukin (IL)-18 with chronic inflammation, we investigated IL-18, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in patients with chronic renal failure (CRF) and patients undergoing continuous ambulatory peritoneal dialysis (CAPD).

METHODS

Plasma was evaluated by ELISA methodology in 15 healthy controls, 27 CRF and 15 CAPD patients.

RESULTS

Plasma IL-18 levels in CRF (572.5 +/- 41.9 pg/ml) or CAPD (479.2 +/- 47.4 pg/ml) were significantly higher than normal (263.6 +/- 20.0 pg/ml), but there was no difference in IL-18 between CRF and CAPD patients. The IL-18 concentration negatively correlated with creatinine clearance (Ccr). However, the duration of dialysis, normalized protein nitrogen appearance, weekly Ccr, and Kt/V(urea) were not correlated with plasma IL-18 in CAPD. The plasma IL-18 concentration was positively correlated with TNF-alpha but not with IL-6 in renal failure patients with or without CAPD.

CONCLUSION

Uremia is the principal origin of increased plasma IL-18 in these patients. Increased IL-18 levels may be associated with Th1 differentiation and elevated TNF-alpha.

摘要

背景/目的：基于白细胞介素（IL）-18与慢性炎症的关联，我们对慢性肾衰竭（CRF）患者和持续性非卧床腹膜透析（CAPD）患者的IL-18、IL-6及肿瘤坏死因子-α（TNF-α）进行了研究。

方法

采用酶联免疫吸附测定（ELISA）法对15名健康对照者、27名CRF患者和15名CAPD患者的血浆进行评估。

结果

CRF患者（572.5±41.9 pg/ml）和CAPD患者（479.2±47.4 pg/ml）的血浆IL-18水平显著高于正常水平（263.6±20.0 pg/ml），但CRF患者与CAPD患者的IL-18水平并无差异。IL-18浓度与肌酐清除率（Ccr）呈负相关。然而，透析时间、标准化蛋白氮呈现率、每周Ccr及Kt/V（尿素）与CAPD患者的血浆IL-18水平并无关联。在有或无CAPD的肾衰竭患者中，血浆IL-18浓度与TNF-α呈正相关，但与IL-6无关。