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1992年至2002年在马达加斯加巴斯德研究所诊断出的宫颈癌

[Cervical cancers diagnosed at the Pasteur Institute of Madagascar from 1992 to 2002].

作者信息

Raharisolo Vololonantenaina C R, Rabarijaona L P, Soares J L, Rasendramino M, Pécarrère J L, Khun H, Huerre M

机构信息

Institut Pasteur de Madagascar, BP 1274, 101 Antananarivo, Madagascar.

出版信息

Arch Inst Pasteur Madagascar. 2003;69(1-2):77-81.

Abstract

In Madagascar, the epidemiological data actualized concerning the cancer of the collus of uterus are not available because of the absence of register of cancer. The objective of this study is to achieve a first assessment of the problem, to complete the epidemiological knowledge, to point out the tool of precoce detection of the precancerous lesions, to propose the measures aiming to improve the management of the patients and to contribute to the institution of a register of cancer. This is a retrospective survey on the frequency of the cancer of the cervix observed from 1992 to 2002 about 23,908 withdrawals addressed to the Institut Pasteur de Madagascar for anatomopathological exam and 12,605 cervical smears for cytological exam. In pathological anatomy, 2,621 (63.4%) of 4,136 cases of diagnosed cancer, have been observed in women. 687 cases (26.2%) of them were localized in the collus. The 3/4 of the cancers of the cervix is invasive and the mean age is 48.2 years old at the time of diagnosis. The cytology detects only 74 cases of invasive cancer of which most don't have an histological confirmation. 274 pre-lesions of cervix cancer were diagnosed for this period, the majority lesions are cytological diagnosis. In spite of a non representative recruitment of the general population, and by the number of withdrawals considered, these results may represent indicators of the epidemiological situation and justify the institution of program to detect the precancerous lesions in a national scale.

摘要

在马达加斯加,由于缺乏癌症登记,目前尚无关于子宫颈癌的最新流行病学数据。本研究的目的是对该问题进行首次评估,完善流行病学知识,指出癌前病变的早期检测工具,提出旨在改善患者管理的措施,并为建立癌症登记制度做出贡献。这是一项回顾性调查,涉及1992年至2002年期间,马达加斯加巴斯德研究所收到的23908份用于解剖病理学检查的样本以及12605份用于细胞学检查的宫颈涂片样本中观察到的宫颈癌发病频率。在病理解剖学方面,在4136例确诊癌症病例中,有2621例(63.4%)为女性患者。其中687例(26.2%)病变局限于宫颈。四分之三的宫颈癌为浸润性癌,确诊时的平均年龄为48.2岁。细胞学检查仅发现74例浸润性癌,其中大多数病例未经组织学确诊。在此期间诊断出274例宫颈癌前病变,大多数病变为细胞学诊断。尽管样本采集并非来自具有代表性的普通人群,且考虑到样本数量,但这些结果仍可能代表流行病学状况指标,并为在全国范围内开展癌前病变检测项目提供依据。

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