Sato Kazuya, Nagai Tadashi, Muroi Kazuo, Komatsu Norio, Ozawa Keiya
Division of Hematology, Jichi Medical School.
Rinsho Ketsueki. 2004 Dec;45(12):1252-4.
We investigated the prevalence of Helicobacter pylori infection and the effect of eradication therapy in patients with idiopathic thrombocytopenic purpura (ITP). H. pylori infection was found in 9 of 11 patients (81.8%). H. pylori eradication was obtained in all patients and significant platelet recovery was found in 5 of 9 patients (55.6%). One patient required re-eradication therapy because the urea breath test remained positive after the first therapy. After complete eradication, long time remission was obtained. The results suggested that the platelet count might be correlated closely with the amount of H. pylori in some patients with H. pylori positive ITP.
我们调查了特发性血小板减少性紫癜(ITP)患者中幽门螺杆菌感染的患病率以及根除治疗的效果。11例患者中有9例(81.8%)发现幽门螺杆菌感染。所有患者均实现了幽门螺杆菌根除,9例患者中有5例(55.6%)血小板显著回升。1例患者因首次治疗后尿素呼气试验仍为阳性而需要再次根除治疗。完全根除后,实现了长期缓解。结果表明,在一些幽门螺杆菌阳性的ITP患者中,血小板计数可能与幽门螺杆菌数量密切相关。