Hattori H, Uemura K, Ishihara H, Ogata H
Laboratory for Cell Biology, Pharma Research Laboratories, Hoechst Japan Limited, Saitama.
Biochim Biophys Acta. 1992 Apr 8;1125(1):21-7. doi: 10.1016/0005-2760(92)90150-t.
Glycolipid isolated from normal and cancerous human pancreatic tissues were characterized chemically and immunologically. The major neutral glycolipids in both normal and cancerous tissues were composed of globo-series glycolipids and lacto-series glycolipids. The mole percentage of fucolipids in the total neutral glycolipids of normal tissues was 20-40%, and in general the fucolipids corresponded to blood group glycolipids related to the patient's blood group, however, in cancerous tissues the amount of these fucolipids was decreased. Immunostaining revealed that normal tissues contained only lacto-series (type 1 chain) glycolipids. In contrast, cancerous tissues contained the neolacto-series (type 2 chain) glycolipids as well as the lacto-series glycolipids. Incompatible blood group antigens, A active glycolipids in a blood type O patient and B active glycolipids in a blood type A patient, were also detectable in the neutral glycolipid fractions of the pancreatic cancer tissues.
对从正常和癌性人类胰腺组织中分离出的糖脂进行了化学和免疫特性分析。正常组织和癌性组织中的主要中性糖脂均由球系列糖脂和乳系列糖脂组成。正常组织总中性糖脂中岩藻糖脂的摩尔百分比为20 - 40%，一般来说，岩藻糖脂与患者血型相关的血型糖脂相对应，然而，在癌性组织中这些岩藻糖脂的含量降低。免疫染色显示正常组织仅含有乳系列（1型链）糖脂。相比之下，癌性组织既含有新乳糖系列（2型链）糖脂，也含有乳系列糖脂。不相容的血型抗原，即O型血患者中的A活性糖脂和A型血患者中的B活性糖脂，在胰腺癌组织的中性糖脂组分中也可检测到。
