Zöllner Tina, Gebhardt Peter, Beckert Rainer, Hertweck Christian
Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11a, 07745 Jena, Germany.
J Nat Prod. 2005 Jan;68(1):112-4. doi: 10.1021/np049728+.
An efficient procedure for the highly selective oxidation of leucomycines to the corresponding 16-membered 9- and 13-oxo macrolides using hypervalent iodinates is presented. Both the Dess-Martin periodinane (DMP) and polymer-bound 2-iodoxybenzoic acid (IBX) show clear advantages over the previously employed manganese dioxide. Key intermediates for a variety of further chemical derivatization methods (2a, 2b) are obtained in very good yields without the requirement of protecting groups.
本文介绍了一种使用高价碘化物将柱晶白霉素高效选择性氧化为相应的16元9-氧代和13-氧代大环内酯的方法。戴斯-马丁高碘烷（DMP）和聚合物负载的2-碘酰基苯甲酸（IBX）均比先前使用的二氧化锰具有明显优势。无需保护基团即可高产率获得多种进一步化学衍生化方法的关键中间体（2a、2b）。
