拮抗Wnt和FGF受体：来自内质网的内部敌人。

Antagonizing Wnt and FGF receptors: an enemy from within (the ER).

作者信息

He Xi

机构信息

Division of Neuroscience, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

出版信息

Cell. 2005 Jan 28;120(2):156-8. doi: 10.1016/j.cell.2005.01.006.

DOI:10.1016/j.cell.2005.01.006

PMID:15680320

Abstract

In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting anterior patterning in Xenopus.

摘要

在本期《细胞》杂志中，山本等人（2005年）描述了一种新型分子Shisa，它在内质网（ER）中发挥作用，阻止卷曲蛋白（Fz）蛇形受体和成纤维细胞生长因子受体（FGFR）的成熟。因此，Shisa以细胞自主方式拮抗Wnt和FGF信号传导，从而促进非洲爪蟾的前部模式形成。