金黄色葡萄球菌鼻腔携带与维生素D受体基因中已知的多态性无关。
Staphylococcus aureus nasal carriage is not associated with known polymorphism in the Vitamin D receptor gene.
作者信息
Claassen Mark, Nouwen Jan, Fang Yue, Ott Alewijn, Verbrugh Henri, Hofman Albert, van Belkum Alex, Uitterlinden André
机构信息
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
出版信息
FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):173-6. doi: 10.1016/j.femsim.2004.08.002.
The vitamin D endocrine system has been shown to influence the immune response and polymorphisms in the vitamin D receptor (VDR) gene have been associated with susceptibility to infectious diseases. We determined if the Cdx2, FokI and BsmI-ApaI-TaqI polymorphisms in the VDR gene were associated with nasal carriage of Staphylococcal aureus. We defined the S. aureus nasal carriage status (persistent, intermittent or non-carriage) for a group of more that 2000 elderly volunteers. The prevalence of persistent S. aureus nasal carriage was 18%, which was, however, not associated with any of the variant VDR genotypes. Our study into genetic determinants of S. aureus carriage patterns is the largest in the field, but still we found no association between VDR gene variation and S. aureus nasal carriage.
维生素D内分泌系统已被证明会影响免疫反应，维生素D受体（VDR）基因的多态性与传染病易感性有关。我们确定了VDR基因中的Cdx2、FokI和BsmI - ApaI - TaqI多态性是否与金黄色葡萄球菌的鼻腔携带有关。我们为一组2000多名老年志愿者定义了金黄色葡萄球菌鼻腔携带状态（持续携带、间歇携带或未携带）。金黄色葡萄球菌持续鼻腔携带的患病率为18%，然而，这与任何VDR基因变异型均无关联。我们对金黄色葡萄球菌携带模式的遗传决定因素的研究是该领域规模最大的，但我们仍然没有发现VDR基因变异与金黄色葡萄球菌鼻腔携带之间存在关联。
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