丹麦中老年双胞胎中宿主遗传学和环境对金黄色葡萄球菌鼻腔携带的影响。
Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.
机构信息
Microbiology and Infection Control, Statens Serum Institut, Copenhagen S, Denmark.
出版信息
J Infect Dis. 2012 Oct;206(8):1178-84. doi: 10.1093/infdis/jis491. Epub 2012 Aug 7.
BACKGROUND
Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown.
METHODS
Nasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers.
RESULTS
The prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected.
CONCLUSION
In this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.
背景
鼻腔携带是金黄色葡萄球菌感染的一个主要危险因素。大约有四分之一的成年人携带金黄色葡萄球菌。然而，宿主遗传学对金黄色葡萄球菌鼻腔携带的作用尚不清楚。
方法
从丹麦中年和老年双胞胎的全国队列中获得鼻腔拭子。通过选择性平板和 spa 分型鉴定出金黄色葡萄球菌定植的受试者。从最初携带一致的双胞胎中获得第二份样本。再次发现定植金黄色葡萄球菌的双胞胎被定义为持续性携带者。
结果
617 对双胞胎（同卵/异卵双胞胎：112/505）中金黄色葡萄球菌携带率为 26.3%（95%置信区间[CI]，24.0%-28.9%）。同卵双胞胎（37.5%；95%CI，22.3%-53.8%）和同性双胞胎（24.2%；95%CI，15.4%-34.5%）之间的携带一致性率与异性双胞胎（21.4%；95%CI，12.0%-33.4%）之间无显著差异。尽管有共同的童年，但只有 617 对双胞胎中的 1 对在谱系方面是一致的。尽管金黄色葡萄球菌和谱系持久性的遗传力增加，但未检测到显著的遗传力。
结论
在这项研究中，宿主遗传因素对中年和老年人金黄色葡萄球菌携带者状态的影响仅适度。
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