TNBS诱导的结肠炎大鼠中，树突状细胞在肠系膜淋巴结中对半抗原化蛋白的呈递及T细胞的激活
The presentation of haptenated proteins and activation of T cells in the mesenteric lymph nodes by dendritic cells in the TNBS colitis rat.
作者信息
Ishiguro Yoh, Sakuraba Hirotake, Yamagata Kazufumi, Munakata Akihiro
机构信息
First Department of Internal medicine, Hirosaki University School of Medicine, 5 zaifu-cho, Hirosaki, Japan.
出版信息
Ann N Y Acad Sci. 2004 Dec;1029:346-7. doi: 10.1196/annals.1309.017.
PMID:15681777
Abstract
We described the role of dendritic cells (DCs) in aspects of T cell activation at the mesenteric lymph nodes (MLN) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. An antigenic-immune response is induced at the MLN, and dendritic cells are the affected cell type. Cross-linking and GRO/CINC-1 have synergistic effects for DC maturation.
摘要
我们描述了树突状细胞（DCs）在三硝基苯磺酸（TNBS）诱导的结肠炎中，于肠系膜淋巴结（MLN）处T细胞活化方面所起的作用。在MLN处诱导了抗原-免疫应答，且树突状细胞是受影响的细胞类型。交联和生长调节致癌基因/趋化因子-1（GRO/CINC-1）对DC成熟具有协同作用。
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