肠道相关淋巴组织中肠道嗜性T细胞的选择性生成：对GALT树突状细胞和佐剂的需求。

Selective generation of gut-tropic T cells in gut-associated lymphoid tissues: requirement for GALT dendritic cells and adjuvant.

作者信息

Svensson Marcus, Johansson-Lindbom Bengt, Wurbel Marc-André, Malissen Bernard, Márquez Gabriel, Agace William

机构信息

Immunology Section, Lund University, BMC I-13, S-22184 Lund, Sweden.

出版信息

Ann N Y Acad Sci. 2004 Dec;1029:405-7. doi: 10.1196/annals.1309.025.

DOI:10.1196/annals.1309.025

PMID:15681793

Abstract

To gain entry into peripheral tissues, effector T lymphocytes express specific combinations of adhesion molecules and chemokine receptors. Expression of these are induced during activation in regional secondary lymphoid organs. Herein, we describe a role for GALT DCs in the generation of CCR9(+) alpha(4)beta(7)(+) gut tropic lymphocytes.

摘要

为进入外周组织，效应T淋巴细胞表达粘附分子和趋化因子受体的特定组合。这些分子的表达在区域二级淋巴器官激活过程中被诱导。在此，我们描述了肠道相关淋巴组织树突状细胞（GALT DCs）在生成CCR9(+)α(4)β(7)(+)肠道归巢淋巴细胞中的作用。