Picchioni Dante, Mignot Emmanuel J, Harsh John R
University of Southern Mississippi, Hattiesburg, USA.
Sleep. 2004 Dec 15;27(8):1471-5. doi: 10.1093/sleep/27.8.1471.
A March peak and a September trough in the birth pattern of narcolepsy patients with clear-cut cataplexy was recently reported. The objectives of the present study were to determine whether the month-of-birth pattern would (a) vary with the presence and severity of cataplexy and (b) differ for patients positive and negative for HLA-DQB1*0602.
Cross-sectional survey with data obtained from the clinical trials assessing the safety and efficacy of modafinil in the treatment of narcolepsy.
Sleep clinics throughout the United States.
A group of 530 narcolepsy patients diagnosed based on the International Classification of Sleep Disorders using clinical histories, nocturnal polysomnography, and Multiple Sleep Latency Tests.
NA.
A surplus of March births and a fall-off in September births was found in narcolepsy relative to the general population. This finding was only observed when cataplexy was moderate or severe. The month-of-birth pattern was similar for HLA-DQB10602 positive and negative patients. A March birth and HLA-DQB10602 positivity were independent risk factors in a logistic regression analysis.
Environmental events during development may influence narcolepsy severity or the likelihood of developing the disease.
最近有报告称，伴有明确猝倒症状的发作性睡病患者的出生模式呈现3月高峰和9月低谷。本研究的目的是确定出生月份模式是否会（a）因猝倒的存在和严重程度而有所不同，以及（b）在HLA - DQB1*0602呈阳性和阴性的患者中存在差异。
横断面调查，数据来自评估莫达非尼治疗发作性睡病安全性和有效性的临床试验。
美国各地的睡眠诊所。
一组530名发作性睡病患者，根据国际睡眠障碍分类，利用临床病史、夜间多导睡眠图和多次睡眠潜伏期测试进行诊断。
无。
与普通人群相比，发作性睡病患者中3月出生的人数过剩，9月出生的人数减少。这一发现仅在猝倒症状为中度或重度时观察到。HLA - DQB10602阳性和阴性患者的出生月份模式相似。在逻辑回归分析中，3月出生和HLA - DQB10602阳性是独立的风险因素。
发育过程中的环境事件可能会影响发作性睡病的严重程度或患病可能性。
