Hashimoto Kenji, Engberg Göran, Shimizu Eiji, Nordin Conny, Lindström Leif H, Iyo Masaomi
Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
BMC Psychiatry. 2005 Jan 31;5:6. doi: 10.1186/1471-244X-5-6.
Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of schizophrenic patients, and absent for glutamine. This study aims to clarify the question of glutamine and glutamate in CSF of first episode and drug naive schizophrenic patients.
Levels of glutamine and glutamate in CSF of 25 first episode and drug-naive male schizophrenic patients and 17 age-matched male healthy controls were measured by a high performance liquid chromatography.
The ratio (126.1 (median), 117.7 +/- 27.4 (mean +/- S.D.)) of glutamine to glutamate in the CSF of patients was significantly (z = -3.29, p = 0.001) higher than that (81.01 (median), 89.1 +/- 22.5 (mean +/- S.D.)) of normal controls although each level of glutamine and glutamate in patients was not different from that of normal controls.
Our data suggests that a disfunction in glutamate-glutamine cycle in the brain may play a role in the pathophysiology of schizophrenia.
最近的磁共振波谱（MRS）研究报告称，精神分裂症患者大脑中的谷氨酰胺发生了改变。关于精神分裂症患者脑脊液（CSF）中的谷氨酸也存在相互矛盾的研究结果，而关于谷氨酰胺的研究则尚无定论。本研究旨在阐明首发未用药精神分裂症患者脑脊液中谷氨酰胺和谷氨酸的问题。
采用高效液相色谱法测量了25例首发未用药男性精神分裂症患者及17例年龄匹配的男性健康对照者脑脊液中谷氨酰胺和谷氨酸的水平。
患者脑脊液中谷氨酰胺与谷氨酸的比值（中位数为126.1，均值±标准差为117.7±27.4）显著高于正常对照者（中位数为81.01，均值±标准差为89.1±22.5）（z = -3.29，p = 0.001），尽管患者脑脊液中谷氨酰胺和谷氨酸的各自水平与正常对照者并无差异。
我们的数据表明，大脑中谷氨酸-谷氨酰胺循环功能障碍可能在精神分裂症的病理生理学中发挥作用。
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