Théberge Jean, Al-Semaan Yousef, Williamson Peter C, Menon Ravi S, Neufeld Richard W J, Rajakumar Nagalingam, Schaefer Betsy, Densmore Maria, Drost Dick J
Department of Nuclear Medicine and Magnetic Resonance, St. Joseph's Health Care, London, Ont., Canada.
Am J Psychiatry. 2003 Dec;160(12):2231-3. doi: 10.1176/appi.ajp.160.12.2231.
This in vivo (1)H magnetic resonance spectroscopy study examined levels of glutamate, glutamine, and N-acetylaspartate in medicated patients with chronic schizophrenia.
Localized in vivo (1)H spectra were acquired at 4.0 T from the left anterior cingulate and thalamus of 21 patients with schizophrenia and 21 comparable healthy volunteers.
Significantly lower levels of glutamine and glutamate were found in the left anterior cingulate cortex of patients with schizophrenia than in the healthy volunteers. For the schizophrenia patients, the glutamine level in the left thalamus was found to be higher than normal, and there was a significant negative correlation between N-acetylaspartate level and duration of positive symptoms.
Since previous studies have found higher than normal levels of glutamine in the left anterior cingulate of never-treated patients, decreased levels of these metabolites in chronic patients could be related to neurodegeneration or the effects of chronic medication.
本体内氢磁共振波谱研究检测了慢性精神分裂症服药患者的谷氨酸、谷氨酰胺和N-乙酰天门冬氨酸水平。
在4.0T磁场下，采集了21例精神分裂症患者及21名健康对照者左侧前扣带回和丘脑的局部体内氢谱。
精神分裂症患者左侧前扣带回皮质的谷氨酰胺和谷氨酸水平显著低于健康对照者。对于精神分裂症患者，发现左侧丘脑的谷氨酰胺水平高于正常，且N-乙酰天门冬氨酸水平与阳性症状持续时间呈显著负相关。
由于既往研究发现未治疗患者左侧前扣带回的谷氨酰胺水平高于正常，慢性患者这些代谢物水平降低可能与神经退行性变或慢性药物治疗的作用有关。
