Shen Li-jia, Xie Si-ming, Yin Cao, Ruan Ping, Yao Xi
Department of Stomatology, Medical College, Jinan University, Guangzhou 510632, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):79-82.
To study the expressions of PTEN, FHIT and cyclin D1 in normal oral mucosa and oral squamous cell carcinoma (OSCC), and analyze the relationship between PTEN/FHIT and cyclin D1.
Immunohistochemical staining with SP methods was used to detect the expression of PTEN, FHIT and cyclin D1 in OSCC tissues in 62 cases and normal oral mucosa in 12 cases.
The positivity rates of PTEN and FHIT were both 100% (12/12) in the normal oral mucosa, while in 62 cases of OSCC, 24.2% (15/62) and 17.7% (11/62) were negative for (or with low expression of) PTEN and FHIT, respectively. In normal oral mucosa, 91.7% (11/12) cases had negative or low cyclin D1 expression, while 53.2% (33/62) of the OSCC cases were positive for cyclin D1 expression. In all the cases, when PTEN and FHIT were strongly expressed, 37.8% (28/74) of the cases had negative or low expression of cyclin D1, including 11 normal cases.
The tumor suppressor genes PTEN and FHIT play a role in the pathogenesis of OSCC, and PTEN and FHIT can down-regulate the expression of cyclin D1.
研究PTEN、FHIT及细胞周期蛋白D1在正常口腔黏膜和口腔鳞状细胞癌（OSCC）中的表达情况，并分析PTEN/FHIT与细胞周期蛋白D1之间的关系。
采用免疫组织化学SP法检测62例OSCC组织及12例正常口腔黏膜组织中PTEN、FHIT及细胞周期蛋白D1的表达。
正常口腔黏膜中PTEN和FHIT的阳性率均为100%（12/12），而在62例OSCC中，PTEN和FHIT阴性（或低表达）分别占24.2%（15/62）和17.7%（11/62）。正常口腔黏膜中91.7%（11/12）的病例细胞周期蛋白D1表达为阴性或低表达，而OSCC病例中有53.2%（33/62）细胞周期蛋白D1表达为阳性。在所有病例中，当PTEN和FHIT强表达时，37.8%（28/74）的病例细胞周期蛋白D1表达为阴性或低表达，其中包括11例正常病例。
抑癌基因PTEN和FHIT在OSCC发病机制中起作用，且PTEN和FHIT可下调细胞周期蛋白D1的表达。
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