Wang Zhi-rui, Zhang Lan-lan, Huang Chang-quan, Zhang Zhong-yi, Lin Jing-ming
Department of Pharmaceutics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):87-8, 92.
To identify the structure of the alkaloid extract of Gelsemium from east Guangdong province of China.
Fourier transform infrared (FTIR) absorption spectrometry, hydrogen and carbon spectra of nuclear magnetic resonance (NMR) and distortionless enhancement by polarization transfer (DEPT) analysis were used for the structural identification of the alkaloid exstract of Gelsemium.
The frequency, intensity and shape of the extract's characteristic peaks in infrared absorption spectra (4,000.0-400.0 cm(-1)) and (1)H NMR, (13)C NMR were recognized and compared. The molecular structure of the sample was consistent with the theoretically derived model.
The extract is structurally identical to koumine, which may provide evidence for its safe clinical application and establishment of Chinese medicine fingerprint database of Gelsemium.
鉴定中国广东省东部钩吻生物碱提取物的结构。
采用傅里叶变换红外（FTIR）吸收光谱法、核磁共振（NMR）氢谱和碳谱以及极化转移无畸变增强（DEPT）分析对钩吻生物碱提取物进行结构鉴定。
识别并比较了提取物在红外吸收光谱（4000.0 - 400.0 cm⁻¹）以及¹H NMR、¹³C NMR中的特征峰频率、强度和形状。样品的分子结构与理论推导模型一致。
该提取物在结构上与钩吻素甲相同，这可能为其临床安全应用及建立钩吻中药指纹图谱数据库提供依据。
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