对钩吻（断肠草）成分钩吻素子的结构重新研究，揭示了一种新型的含氮杂环丁烷吲哚生物碱。

Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid.

作者信息

Kitajima Mariko, Kogure Noriyuki, Yamaguchi Kentaro, Takayama Hiromitsu, Aimi Norio

机构信息

Graduate School of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

出版信息

Org Lett. 2003 Jun 12;5(12):2075-8. doi: 10.1021/ol0344725.

DOI:10.1021/ol0344725

PMID:12790532

Abstract

[structure: see text] The structure of gelsemoxonine, isolated from Gelsemium elegans Benth., was revised to be a novel oxindole alkaloid having an azetidine unit. A new alkaloid, 14,15-dihydroxygelsenicine, which was presumed to be a biosynthetic precursor of gelsemoxonine, was also isolated.

摘要

[结构：见正文] 从断肠草（Gelsemium elegans Benth.）中分离得到的钩吻素子的结构被修正为一种具有氮杂环丁烷单元的新型氧化吲哚生物碱。还分离得到了一种新的生物碱14,15 - 二羟基钩吻素甲，它被推测为钩吻素子的生物合成前体。