Xie Fang-ming, Zeng Kang, Li Guo-feng, Lin Zhong-fang, Sun Le-dong
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Jan;25(1):99-101.
To improve the therapeutic efficacy and reduce the adverse effect of podophyllotoxin (PPT) by wrapping it in stearic acid solid lipid nanoparticles.
Stearic acid solid lipid nanoparticles containing podophyllotoxin was prepared using modified microemulsion technique, whose morphology was examined by transmission electron microscope. High-performance of liquid chromatography was employed to determine the entrapment efficiency of PPT in the nanoparticles.
The entrapment efficiency of PPT in the nanoparticles was 85.6% and the mean diameter of the particles was 56.5+/-25.8 nm.
The stearic acid solid lipid nanoparticles has high entrapment efficiency for PPT and is homogeneous in size, which can be a promising targeted preparation for epidermal delivery.
通过将鬼臼毒素（PPT）包裹于硬脂酸固体脂质纳米粒中，提高其治疗效果并降低不良反应。
采用改良微乳技术制备含鬼臼毒素的硬脂酸固体脂质纳米粒，通过透射电子显微镜观察其形态。采用高效液相色谱法测定纳米粒中鬼臼毒素的包封率。
纳米粒中鬼臼毒素的包封率为85.6%，平均粒径为56.5±25.8nm。
硬脂酸固体脂质纳米粒对鬼臼毒素具有较高的包封率且粒径均匀，有望成为一种有前景的表皮给药靶向制剂。
Zotero 插件