Karande Sunil, Satam Nitin, Kulkarni Madhuri, Bharadwaj Renu, Pol Sae
Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, India.
Indian J Pediatr. 2005 Jan;72(1):86. doi: 10.1007/BF02760593.
Severe leptospirosis rarely presents with primary pulmonary manifestations, without any associated jaundice or renal dysfunction. The authors report a nine-year-old boy who presented with complaints of abrupt onset of high fever; with myalgia, headache, and pain in right chest region, productive cough with hemoptysis and vomiting developing over the past 72 hours. Chest radiograph showed consolidation in the right upper lobe with air bronchogram. A history of contact with sewage water and presence of conjunctival suffusion in a child with pneumonia made us suspect leptospirosis. Following prompt initiation of parenteral penicillin therapy the child's complaints resolved over the next five days. Dri-Dot test to detect anti-Leptospira antibodies was positive. The diagnosis of leptospirosis was confirmed by a positive microagglutination test to Leptospira interrogans serovar Australis by a fourfold rise in antibody titer in paired sera collected during convalescence. Leptospirosis presenting with pulmonary hemorrhage has been associated with significant mortality but it can be successfully treated with early clinical suspicion of alveolar hemorrhage and prompt therapy.
严重钩端螺旋体病很少以原发性肺部表现为首发症状,且无任何相关黄疸或肾功能不全。作者报告了一名9岁男孩,他主诉突然高热;伴有肌痛、头痛和右胸区域疼痛,在过去72小时内出现咳痰伴咯血和呕吐。胸部X线片显示右上叶实变并伴有空气支气管征。一名肺炎患儿有接触污水史且存在结膜充血,这使我们怀疑为钩端螺旋体病。在迅速开始静脉注射青霉素治疗后,患儿的症状在接下来的五天内得到缓解。检测抗钩端螺旋体抗体的Dri-Dot试验呈阳性。通过对钩端螺旋体澳洲血清型进行显微凝集试验呈阳性,且恢复期采集的配对血清中抗体滴度呈四倍升高,从而确诊为钩端螺旋体病。表现为肺出血的钩端螺旋体病与显著的死亡率相关,但通过早期临床怀疑肺泡出血并及时治疗可成功治愈。