Morikawa Masa-Aki, Yoshihara Masakuni, Endo Takeshi, Kimizuka Nobuo
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
J Am Chem Soc. 2005 Feb 9;127(5):1358-9. doi: 10.1021/ja043844h.
Supramolecular nanowires are specifically self-assembled from adenosine 5'-triphosphate (ATP) and dichloro-substituted thiacarbocyanine dyes. Spectral blue-shift and induced circular dichroism with exciton coupling are observed upon mixing the dye and ATP molecules in water. These observations indicate the formation of chiral 1/ATP supramolecular assemblies with excitation energy delocalized in the parallel-oriented (H-aggregated) chromophores. Interestingly, formation of H-aggregates is facilitated most in the presence of ATP and not by other nucleotides (ADP or AMP). In electron microscopy, aqueous 1/ATP mixture gives developed nanowires with a minimum width of ca. 10 nm and lengths of several micrometers. The ATP-directed nanowires exhibit reversible thermal self-assembly accompanied by supramolecular thermochromism. This is the first example of ATP-based supramolecular nanoassemblies, and the use of small biomolecules as building blocks for functional supermolecules provides a new perspective in the design of bio-nanomaterials.
超分子纳米线是由5'-三磷酸腺苷（ATP）和二氯取代的硫代碳菁染料特异性自组装而成。将染料和ATP分子在水中混合时，会观察到光谱蓝移以及激子耦合诱导的圆二色性。这些观察结果表明形成了手性1/ATP超分子聚集体，其激发能在平行取向（H-聚集）的发色团中离域。有趣的是，在ATP存在下H-聚集体的形成最为有利，而其他核苷酸（ADP或AMP）则不然。在电子显微镜下，水性1/ATP混合物可形成宽度至少约为10 nm、长度为几微米的纳米线。ATP导向的纳米线表现出可逆的热自组装，并伴有超分子热致变色现象。这是基于ATP的超分子纳米组装体的首个实例，并且使用小生物分子作为功能性超分子的构建块为生物纳米材料的设计提供了新的视角。
