网格蛋白介导和非网格蛋白介导的细胞信号内吞调节

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.

作者信息

Le Roy Christine, Wrana Jeffrey L

机构信息

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Room 1075, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

出版信息

Nat Rev Mol Cell Biol. 2005 Feb;6(2):112-26. doi: 10.1038/nrm1571.

DOI:10.1038/nrm1571

PMID:15687999

Abstract

The internalization of various cargo proteins and lipids from the mammalian cell surface occurs through the clathrin and lipid-raft endocytic pathways. Protein-lipid and protein-protein interactions control the targeting of signalling molecules and their partners to various specialized membrane compartments in these pathways. This functions to control the activity of signalling cascades and the termination of signalling events, and therefore has a key role in defining how a cell responds to its environment.

摘要

哺乳动物细胞表面各种货物蛋白和脂质的内化是通过网格蛋白和脂筏内吞途径发生的。蛋白质-脂质和蛋白质-蛋白质相互作用控制着信号分子及其伴侣在这些途径中靶向各种特殊膜区室。这一过程起到控制信号级联反应的活性和信号事件终止的作用，因此在确定细胞如何对其环境做出反应方面起着关键作用。