ADAMs：表皮生长因子受体信号传导与发育中的关键组成部分。
ADAMs: key components in EGFR signalling and development.
作者信息
Blobel Carl P
机构信息
Arthritis and Tissue Degeneration Program and Cell Biology Program, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, New York 10021, USA.
出版信息
Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. doi: 10.1038/nrm1548.
ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.
ADAM（一种解整合素和金属蛋白酶）蛋白是膜锚定金属蛋白酶，可加工并释放膜锚定生长因子、细胞因子和受体的胞外域。ADAM在受精、血管生成、神经发生、心脏发育和癌症中也发挥着重要作用。对ADAM及其在蛋白质胞外域脱落中作用的研究，正成为获取有关膜蛋白功能调控新见解的肥沃土壤。
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