贪食症综合征中的5HTTLPR多态性、精神病理症状及血小板[3H-]帕罗西汀结合情况
The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes.
作者信息
Steiger Howard, Joober Ridha, Israël Mimi, Young Simon N, Ng Ying Kin Ng Mien Kwong, Gauvin Lise, Bruce Kenneth R, Joncas Jasmine, Torkaman-Zehi Adam
机构信息
Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada.
出版信息
Int J Eat Disord. 2005 Jan;37(1):57-60. doi: 10.1002/eat.20073.
BACKGROUND
A short (s) allele in the promoter region of the 5-hydroxytryptamine (5-HT) transporter gene (5HTTLPR) has been associated with low transcription of the 5-HT transporter protein, and with clinical manifestations including impulsivity, affective disorder, and bulimia nervosa.
METHODS
We studied implications of the 5HTTLPR s allele for eating symptoms, psychopathologic traits, and platelet [3H-] paroxetine binding in 59 women with bulimia spectrum syndromes.
RESULTS
Compared with those without it, carriers of the s allele of 5HTTLPR showed significantly more affective instability, behavioral impulsivity, interpersonal insecurity, comorbid borderline personality disorder (BPD), and lower density (Bmax) of paroxetine-binding sites.
CONCLUSIONS
Our results suggest that proneness to impulsivity, affective dysregulation, and reduced central 5-HT reuptake may (in part) be codetermined by the 5HTTLPR polymorphism. However, given inconsistent 5HTTLPR expression in different populations, we speculate that we may be observing a phenotype (i.e., eating disorder)-dependent manifestation.
背景
5-羟色胺（5-HT）转运体基因（5HTTLPR）启动子区域的一个短（s）等位基因与5-HT转运体蛋白的低转录相关，并与包括冲动性、情感障碍和神经性贪食症在内的临床表现有关。
方法
我们研究了5HTTLPR s等位基因对59名患有贪食症谱系综合征女性的饮食症状、精神病理特征和血小板[3H-]帕罗西汀结合的影响。
结果
与没有该等位基因的女性相比，5HTTLPR s等位基因携带者表现出明显更多的情感不稳定、行为冲动性、人际不安全感、共病边缘型人格障碍（BPD）以及帕罗西汀结合位点的较低密度（Bmax）。
结论
我们的结果表明，冲动性倾向、情感失调和中枢5-HT再摄取减少可能（部分）由5HTTLPR多态性共同决定。然而，鉴于5HTTLPR在不同人群中的表达不一致，我们推测我们可能正在观察到一种依赖于表型（即饮食失调）的表现。
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