Goraca Anna
Department of Experimental and Clinical Physiology, Institute of Physiology and Biochemistry, Medical University of Lodz, Poland.
Endocr Regul. 2004 Sep;38(3):119-25.
Magnocellular neuroendocrine cells of the supraoptic nucleus of the hypothalamus produce and release the hormones vasopressin and oxytocin in response to a variety of stimuli to regulate body water and salt as well as and parturition and lactation. The aim of the present study was to estimate oxytocin release into the blood dialysate outflowing from the vicinity of the cavernous sinus and from the femoral vein after NMDA (N-methyl-D-aspartic acid) infusion or acute hypoxia.
The samples of dialysates of venous blood outflowing from the vicinity of the cavernous sinus and, for comparison, from the femoral vein were collected in anesthetized rats. Oxytocin was determined in the sample of dialysates by radioimmunoassay.
NMDA acid infusion or acute hypoxia caused an increase of oxytocin concentration in the blood dialysate outflowing from the vicinity of the cavernous sinus of the sella turcica and from the femoral vein. A blockade of the NMDA receptors by specific and non-specific antagonists significantly inhibited the increase in the blood dialysate oxytocin concentration.
The results indicate the involvement of excitatory amino acid or acute hypoxia in the control of oxytocin release into the blood.
下丘脑视上核的大细胞神经内分泌细胞可响应多种刺激产生并释放血管加压素和催产素，以调节机体水盐平衡以及分娩和泌乳。本研究的目的是评估在输注N-甲基-D-天冬氨酸（NMDA）或急性缺氧后，催产素释放到从海绵窦附近和股静脉流出的血液透析液中的情况。
在麻醉大鼠中收集从海绵窦附近流出的静脉血透析液样本，并作为比较，同时收集从股静脉流出的静脉血透析液样本。通过放射免疫分析法测定透析液样本中的催产素。
输注NMDA或急性缺氧导致从蝶鞍海绵窦附近和股静脉流出的血液透析液中催产素浓度升高。特异性和非特异性拮抗剂对NMDA受体的阻断显著抑制了血液透析液中催产素浓度的升高。
结果表明兴奋性氨基酸或急性缺氧参与了对催产素释放到血液中的控制。
