Tselevych M V, Mandzynets' S M, Sanahurs'kyĭ D I
Fiziol Zh (1994). 2004;50(5):64-8.
The influence of some antibiotics of the fluoroquinolone classes on the Na+, K(+)-ATP-ase activity of loach embryo (Misqurnus fossilis L.) was investigated at different stages of blastomer divisions. It was determined that norofloxacin and borocin induce a dose-dependent decrease in Na+, K(+)-ATP-ase activity. Addition of norofloxacin (5.25 mcg/ml) into the incubation media caused pronounced oscillations in Na+, K(+)-ATP-ase activity, following borocin addition (5,15.25 mcg/ml) this effect was less pronounced. A conclusion was drawn about the influence of the fluoroquinolone on the membrane level.
