Buckstein Rena, Pennell Nancy, Berinstein Neil L
The Advanced Therapeutics Program, Toronto-Sunnybrook Regional Cancer Centre, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ont., Canada M4N 3M5.
Best Pract Res Clin Haematol. 2005 Mar;18(1):27-56. doi: 10.1016/j.beha.2004.08.019.
Follicular lymphoma (FL) is a unique disease characterised by a long natural history and responsiveness to many different therapies. We have reviewed the prognostic significance of the quality of both clinical and molecular responses for patients with FL. We have found that, as might be expected, patients who achieve a complete clinical response to treatment have a better prognosis than patients who achieve an incomplete or a partial response. However, unlike aggressive lymphomas, treatments that produce a higher frequency of complete responses do not result in better survival outcomes than treatments that produce lower complete response rates. Recent improvements in technologies have enabled quantitative monitoring of responses at the molecular level and at much higher degrees of sensitivity than can be obtained at the clinical level. Although these data are very heterogeneous and have many limitations, data are emerging that demonstrate that achieving molecular remissions after standard dose chemotherapy, high dose chemotherapy or various immunotherapies may have prognostic significance for patients with FL. With sensitive, quantitative, standardised and reproducible tools for molecular monitoring and with the combination of novel targeted biological therapies, we are approaching an era, where the potential to cure patients with FL is being turned into a reality.
滤泡性淋巴瘤（FL）是一种独特的疾病，其特点是自然病程长且对多种不同疗法有反应。我们回顾了FL患者临床反应和分子反应质量的预后意义。我们发现，正如预期的那样，治疗后达到完全临床缓解的患者比达到不完全或部分缓解的患者预后更好。然而，与侵袭性淋巴瘤不同，产生较高完全缓解率的治疗方法并不比产生较低完全缓解率的治疗方法带来更好的生存结果。技术上的最新进展使得能够在分子水平上对反应进行定量监测，且灵敏度比临床水平所能达到的要高得多。尽管这些数据非常异质且有许多局限性，但越来越多的数据表明，在标准剂量化疗、高剂量化疗或各种免疫治疗后实现分子缓解可能对FL患者具有预后意义。借助用于分子监测的灵敏、定量、标准化和可重复的工具，以及新型靶向生物疗法的联合应用，我们正在迈向一个时代，在这个时代，治愈FL患者的潜力正在变为现实。
