Ichim Christine V
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
J Transl Med. 2005 Feb 8;3(1):8. doi: 10.1186/1479-5876-3-8.
Experimental and clinical experience demonstrates that the resolution of a pathogenic challenge depends not only on the presence or absence of an immune reaction, but also on the initiation of the proper type of immune reaction. The initiation of a non-protective type of immune reaction will not only result in a lack of protection, but may also exacerbate the underlying condition. For example, in cancer, constituents of the immune system have been shown to augment tumor proliferation, angiogenesis, and metastases. This review discusses the duality of the role of the immune system in cancer, from the theories of immunosurveillance and immunostimulation to current studies, which illustrate that the immune system has both a protective role and a tumor-promoting role in neoplasia. The potential of using chemotherapy to inhibit a tumor-promoting immune reaction is also discussed.
实验和临床经验表明，病原体挑战的解决不仅取决于免疫反应的存在与否，还取决于适当类型免疫反应的启动。非保护性免疫反应的启动不仅会导致缺乏保护，还可能加重潜在病情。例如，在癌症中，免疫系统的成分已被证明会促进肿瘤增殖、血管生成和转移。本综述讨论了免疫系统在癌症中作用的双重性，从免疫监视和免疫刺激理论到当前研究，这些研究表明免疫系统在肿瘤形成中既具有保护作用又具有促肿瘤作用。还讨论了使用化疗抑制促肿瘤免疫反应的潜力。
