[呼吸系统疾病住院患者抗菌药物使用及不良反应调查]
[Survey of the utilization and adverse effects of antibacterial drugs in patients admitted for respiratory diseases].
作者信息
Zhang Qing, Xu Jun, Zheng Ping, Chen Ying
机构信息
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):236-8.
OBJECTIVE
To evaluate the utilization of antibacterial drugs and their adverse effects in patients admitted for respiratory disease based on medical record review.
METHODS
The medical records of 141 inpatients admitted in 2002 for respiratory diseases were reviewed. The drug utilization index (DUI) and daily cost of antibacterial drugs were calculated, with also assessment of the adverse effects in relation to the drug use.
RESULTS
The DUI ranged from 0.9 to 1.1 in 66.7% of the patients, and the daily cost of the antibacterial drugs was 317.8+/-194.3 RMB, with a total of 14 cases with adverse drug effects recorded.
CONCLUSIONS
The utilization of antibacterial drugs was basically adequate in Nanfang Hospital though with occasional abuse of cefoperazone and sulbactam, inappropriate combination and high cost of the antibacterial drugs. More careful application of these drugs in old patients is stressed.
目的
通过病历回顾评估呼吸疾病住院患者抗菌药物的使用情况及其不良反应。
方法
回顾了2002年收治的141例呼吸疾病住院患者的病历。计算了药物利用指数（DUI）和抗菌药物每日费用，并评估了与药物使用相关的不良反应。
结果
66.7%的患者DUI在0.9至1.1之间，抗菌药物每日费用为317.8±194.3元人民币，共记录到14例药物不良反应病例。
结论
南方医院抗菌药物的使用基本合理，但存在头孢哌酮舒巴坦偶尔滥用、联合用药不当以及抗菌药物费用较高的情况。强调在老年患者中更谨慎地使用这些药物。
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