Rimes K A, Chalder T
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Occup Med (Lond). 2005 Jan;55(1):32-9. doi: 10.1093/occmed/kqi015.
To review studies evaluating the treatment of chronic fatigue and chronic fatigue syndrome, to describe predictors of response to treatment and to discuss the role of the occupational health physician.
A literature search was carried out using Medline and PsychInfo.
Studies evaluating cognitive behaviour therapy, graded exercise therapy, pharmacological interventions (e.g. antidepressants and corticosteroids), immunological interventions and nutritional supplements were reviewed. The most promising results have been found with cognitive behaviour therapy and graded exercise therapy, and some predictors of outcome have been identified. Most of the other interventions were evaluated in just one or two studies and therefore evidence is insufficient to draw firm conclusions.
By applying the models of fatigue that form the bases for cognitive behaviour therapy and graded exercise therapy, occupational health physicians may play an important role in helping the patients with chronic fatigue syndrome to reduce their symptoms, improve their functioning and return to work.
回顾评估慢性疲劳和慢性疲劳综合征治疗方法的研究，描述治疗反应的预测因素，并讨论职业健康医生的作用。
使用Medline和PsychInfo进行文献检索。
对评估认知行为疗法、分级运动疗法、药物干预（如抗抑郁药和皮质类固醇）、免疫干预和营养补充剂的研究进行了综述。认知行为疗法和分级运动疗法取得了最有前景的结果，并且已经确定了一些结果的预测因素。大多数其他干预措施仅在一两项研究中进行了评估，因此证据不足，无法得出确凿结论。
通过应用构成认知行为疗法和分级运动疗法基础的疲劳模型，职业健康医生在帮助慢性疲劳综合征患者减轻症状、改善功能和重返工作岗位方面可能发挥重要作用。
