Alexopoulos A, Lachhwani D K, Gupta A, Kotagal P, Harrison A M, Bingaman W, Wyllie E
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Neurology. 2005 Feb 8;64(3):567-70. doi: 10.1212/01.WNL.0000150580.40019.63.
Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.
