Rathmann Silvia, Rajasalu Tarvo, Rosinger Silke, Schlosser Michael, Eiermann Thomas, Boehm Bernhard O, Durinovic-Belló Ivana
Department of Internal Medicine I, Division of Endocrinology, University of Ulm, Robert-Koch Str. 8, 89081 Ulm, Germany.
Ann N Y Acad Sci. 2004 Dec;1037:22-5. doi: 10.1196/annals.1337.004.
In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.
在动物模型中，自身反应性CD8(+) T细胞在1型糖尿病（T1D）的发病过程中起关键作用；然而，它们在人类T1D中的作用仍不清楚。为了探究CD8(+) T细胞的作用，我们进行了一项初步研究，通过用94种胰岛素原（PPI）肽体外刺激后，研究CD8(+) T细胞介导的细胞因子分泌。我们能够证明，在人类T1D中，CD8(+) T细胞对PPI具有强烈的IFNγ反应性。进一步确定表位特异性、细胞因子分泌和细胞毒性能力的研究，对于阐明它们在T1D发病过程中的作用很重要。
